Folate supplementation during pregnancy improves offspring cardiovascular dysfunction Induced by protein restriction

Torrens, Christopher, Brawley, Lee, Anthony, Frederick W., Dance, Caroline S., Dunn, Rebecca, Jackson, Alan A., Poston, Lucilla and Hanson, Mark A. (2006) Folate supplementation during pregnancy improves offspring cardiovascular dysfunction Induced by protein restriction. Hypertension, 47, (5), 982-987. (doi:10.1161/01.HYP.0000215580.43711.d1).


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Dietary protein restriction in the rat compromises the maternal cardiovascular adaptations to pregnancy and leads to raised blood pressure and endothelial dysfunction in the offspring. In this study we have hypothesized that dietary folate supplementation of the low-protein diet will improve maternal vascular function and also restore offspring cardiovascular function. Pregnant Wistar rats were fed either a control (18% casein) or protein-restricted (9% casein) diet +/-5 mg/kg folate supplement. Function of isolated maternal uterine artery and small mesenteric arteries from adult male offspring was assessed, systolic blood pressure recorded, and offspring thoracic aorta levels of endothelial nitric oxide (NO) synthase mRNA measured. In the uterine artery of late pregnancy dams, vasodilatation to vascular endothelial growth factor was attenuated in the protein-restricted group but restored with folate supplementation, as was isoprenaline-induced vasodilatation (P<0.05). In male offspring, protein restriction during pregnancy led to raised systolic blood pressure (P<0.01), impaired acetylcholine-induced vasodilatation (P<0.01), and reduced levels of endothelial NO synthase mRNA (P<0.05). Maternal folate supplementation during pregnancy prevented this elevated systolic blood pressure associated with a protein restriction diet. With folate supplementation, endothelium-dependent vasodilatation and endothelial NO synthase mRNA levels were not significantly different from either the control or protein-restricted groups. Maternal folate supplementation of the control diet had no effect on blood pressure or vasodilatation. This study supports the hypothesis that folate status in pregnancy can influence fetal development and, thus, the risks of cardiovascular disease in the next generation. The concept of developmental origins of adult disease focuses predominately on fetal life but must also include a role for maternal cardiovascular function.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1161/01.HYP.0000215580.43711.d1
ISSNs: 0194-911X (print)
Related URLs:
Keywords: acid, adult, animals, animals, newborn, arteries, blood, blood pressure, cardiovascular disease, cardiovascular diseases, diet, diet, protein-restricted, disease, drug effects, endothelium, vascular, etiology, female, fetal, fetal development, folic acid, growth, health, hypothesis, male, nitric oxide, pharmacology, physiopathology, pregnancy, pregnancy complications, cardiovascular, pressure, protein, rats, rats, wistar, research support, non-U.S.Gov't, risk, vasodilation, vitamin b complex
Subjects: R Medicine > RB Pathology
R Medicine > RG Gynecology and obstetrics
Q Science > QP Physiology
Divisions : University Structure - Pre August 2011 > School of Medicine > Developmental Origins of Health and Disease
ePrint ID: 44248
Accepted Date and Publication Date:
May 2006Published
Date Deposited: 20 Feb 2007
Last Modified: 31 Mar 2016 12:18

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