Role of deficient type III interferon-λ production in asthma exacerbations
Contoli, Marco, Message, Simon D., Laza-Stanca, Vasile, Edwards, Michael R., Wark, Peter A.B., Bartlett, Nathan W., Kebadze, Tatiana, Mallia, Patrick, Stanciu, Luminita A., Parker, Hayley L., Slater, Louise, Lewis-Antes, Anita, Kon, Onn M., Holgate, Stephen T., Davies, Donna E., Kotenko, Sergei V., Papi, Alberto and Johnston, Sebastian L. (2006) Role of deficient type III interferon-λ production in asthma exacerbations. Nature Medicine, 12, (9), 1023-1026. (doi:10.1038/nm1462).
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Rhinoviruses are the major cause of asthma exacerbations, and asthmatics have increased susceptibility to rhinovirus and risk of invasive bacterial infections. Here we show deficient induction of interferon-λs by rhinovirus in asthmatic primary bronchial epithelial cells and alveolar macrophages, which was highly correlated with severity of rhinovirus-induced asthma exacerbation and virus load in experimentally infected human volunteers. Induction by lipopolysaccharide in asthmatic macrophages was also deficient and correlated with exacerbation severity. These results identify previously unknown mechanisms of susceptibility to infection in asthma and suggest new approaches to prevention and/or treatment of asthma exacerbations.
|Digital Object Identifier (DOI):||doi:10.1038/nm1462|
|Additional Information:||Brief communication|
|Subjects:||Q Science > QR Microbiology > QR355 Virology
R Medicine > RF Otorhinolaryngology
|Divisions:||University Structure - Pre August 2011 > School of Medicine > Infection, Inflammation and Repair
|Date Deposited:||22 Feb 2007|
|Last Modified:||06 Aug 2015 02:36|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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