Role of deficient type III interferon-? production in asthma exacerbations

Contoli, Marco, Message, Simon D., Laza-Stanca, Vasile, Edwards, Michael R., Wark, Peter A.B., Bartlett, Nathan W., Kebadze, Tatiana, Mallia, Patrick, Stanciu, Luminita A., Parker, Hayley L., Slater, Louise, Lewis-Antes, Anita, Kon, Onn M., Holgate, Stephen T., Davies, Donna E., Kotenko, Sergei V., Papi, Alberto and Johnston, Sebastian L. (2006) Role of deficient type III interferon-? production in asthma exacerbations. Nature Medicine, 12, (9), 1023-1026. (doi:10.1038/nm1462).


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Rhinoviruses are the major cause of asthma exacerbations, and asthmatics have increased susceptibility to rhinovirus and risk of invasive bacterial infections. Here we show deficient induction of interferon-?s by rhinovirus in asthmatic primary bronchial epithelial cells and alveolar macrophages, which was highly correlated with severity of rhinovirus-induced asthma exacerbation and virus load in experimentally infected human volunteers. Induction by lipopolysaccharide in asthmatic macrophages was also deficient and correlated with exacerbation severity. These results identify previously unknown mechanisms of susceptibility to infection in asthma and suggest new approaches to prevention and/or treatment of asthma exacerbations.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1038/nm1462
Additional Information: Brief communication
ISSNs: 1078-8956 (print)
Related URLs:
Subjects: Q Science > QR Microbiology > QR355 Virology
R Medicine > RF Otorhinolaryngology
Divisions : University Structure - Pre August 2011 > School of Medicine > Infection, Inflammation and Repair
ePrint ID: 44289
Accepted Date and Publication Date:
Date Deposited: 22 Feb 2007
Last Modified: 31 Mar 2016 12:18

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