Phosphonioalkylthiosulfate zwitterions - new masked thiol ligands for the formation of cationic functionalised gold nanoparticles
Ju-Nam, Y., Bricklebank, N., Allen, D.W., Gardiner, P.H.E., Light, M.E. and Hursthouse, M.B. (2006) Phosphonioalkylthiosulfate zwitterions - new masked thiol ligands for the formation of cationic functionalised gold nanoparticles. Organic & Biomolecular Chemistry, 4, (23), 4345-4351. (doi:10.1039/b610480k).
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Description/Abstract
We report the synthesis and structural characterisation of a new family of stable phosphonioalkylthiosulfate zwitterions, R3P+(CH2)(n)S2O3- (R = Ph or Bu, n = 3,4,6, 8 or 10) which behave as cationic masked thiolate ligands with applications in the functionalisation of gold nanoparticles, having potential as new diagnostic biorecognition systems. The ligands were prepared by treatment of omega-bromoalkylphosphonium salts with sodium thiosulfate. The crystal and molecular structures of the zwitterions (R = Ph, n = 3) and ( R = Bu, n = 3) were determined. A series of phosphonioalkanethiolate-capped gold nanoparticles dispersed in water was prepared by borohydride reduction of potassium tetrachloroaurate in the presence of the zwitterions in a dichloromethane-water system. UV-visible spectroscopy and scanning transmission electron-microscopy indicated that capped nanoparticles of ca. 5 nm diameter were present.
| Item Type: | Article |
|---|---|
| ISSNs: | 1477-0520 (print) |
| Related URLs: | |
| Subjects: | Q Science Q Science > QD Chemistry |
| Divisions: | University Structure - Pre August 2011 > School of Chemistry |
| Item ID: | 44469 |
| Date Deposited: | 06 Mar 2007 |
| Last Modified: | 01 Jun 2011 00:08 |
| Contributors: | Ju-Nam, Y. (Author) Bricklebank, N. (Author) Allen, D.W. (Author) Gardiner, P.H.E. (Author) Light, M.E. (Author) Hursthouse, M.B. (Author) |
| Date: | 2006 |
| Status: | Published |
| URI: | http://eprints.soton.ac.uk/id/eprint/44469 |
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