Bronchoalveolar lavage MMP-9 and TIMP-1 in preschool wheezers and their relationship to persistent wheeze
Erlewyn-Lajeunesse, Michel D.S., Hunt, Linda P., Pohunek, Petr, Dobson, Sarah J., Kochhar, Puja, Warner, Jane A. and Warner, John O. (2008) Bronchoalveolar lavage MMP-9 and TIMP-1 in preschool wheezers and their relationship to persistent wheeze. Pediatric Research, 64, (2), 194-199. (doi:10.1203/PDR.0b013e318175dd2d). (PMID:18391843).
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Description/Abstract
AB Atopic preschool children are more likely to develop persistent wheezing, which could be a consequence of early airway remodeling. Protease-antiprotease balance between MMP-9 and its cognate inhibitor TIMP-1 may be involved in this process. Our hypothesis was that atopic wheezing preschool children would have an imbalance of MMP-9 to TIMP-1 in bronchoalveolar lavage (BAL). BAL from 52 preschool wheezers was compared with 14 controls without wheeze. A subgroup completed an International Study of Asthma and Allergy in Childhood symptom questionnaire 2 y later. Molar ratios of MMP-9/TIMP-1 were higher in wheezy children (p < 0.001; median 4.0%, range 0-8.7) than controls (0.6%, 0-1.8), and showed an excess of TIMP-1 in the airway. BAL TIMP-1 was raised in children with persistent wheezing (p = 0.028; 34.4 ng/mL, 9.1-93.1 compared with 10.6 ng/mL 6.1-18.6), as was serum levels of intercellular adhesion molecule-1 (p = 0.027). The absolute concentration of TIMP-1 in the airway, rather than its molar ratio with MMP-9, was associated with persistent wheezing. The processes involved with airway remodeling are complex but excess TIMP-1 may impede matrix protein turnover and thereby contribute to persistent changes in airway structure and wheezing
| Item Type: | Article |
|---|---|
| ISSNs: | 0031-3998 (print) |
| Subjects: | R Medicine > RJ Pediatrics |
| Divisions: | University Structure - Pre August 2011 > School of Medicine > Infection, Inflammation and Repair |
| Item ID: | 45460 |
| Date Deposited: | 18 Feb 2010 |
| Last Modified: | 25 Apr 2013 15:23 |
| Contributors: | Erlewyn-Lajeunesse, Michel D.S. (Author) Hunt, Linda P. (Author) Pohunek, Petr (Author) Dobson, Sarah J. (Author) Kochhar, Puja (Author) Warner, Jane A. (Author) Warner, John O. (Author) |
| Date: | August 2008 |
| Status: | Published |
| Contact Email Address: | mel1z07@soton.ac.uk |
| URI: | http://eprints.soton.ac.uk/id/eprint/45460 |
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