Multistep Synthesis on SU-8: Combining Microfabrication and Solid-Phase Chemistry on a Single Material


Cavalli, Gabriel, Banu, Shahanara, Ranasinghe, Rohan T., Broder, Graham R., Martins, Hugo F.P., Neylon, Cameron, Morgan, Hywel, Bradley, Mark and Roach, Peter L. (2007) Multistep Synthesis on SU-8: Combining Microfabrication and Solid-Phase Chemistry on a Single Material. Journal of Combinatorial Chemistry, 9, (3), 462-472. (doi:10.1021/cc060079p).

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Original Publication URL: http://dx.doi.org/10.1021/cc060079p

Description/Abstract

SU-8 is an epoxy-novolac resin and a well-established negative photoresist for microfabrication and microengineering. The photopolymerized resist is an extremely highly crosslinked polymer showing outstanding chemical and physical robustness with residual surface epoxy groups amenable for chemical functionalization. In this paper we describe, for the first time, the preparation and surface modification of SU-8 particles shaped as microbars, the attachment of appropriate linkers, and the successful application of these particles to multistep solid-phase synthesis leading to oligonucleotides and peptides attached in an unambiguous manner to the support surface.

Item Type: Article
ISSNs: 1520-4766 (print)
Related URLs:
Subjects: T Technology > TP Chemical technology
Q Science > QD Chemistry
Divisions: University Structure - Pre August 2011 > School of Chemistry
ePrint ID: 46382
Date Deposited: 27 Jun 2007
Last Modified: 27 Mar 2014 18:30
URI: http://eprints.soton.ac.uk/id/eprint/46382

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