Multistep Synthesis on SU-8: Combining Microfabrication and Solid-Phase Chemistry on a Single Material
Cavalli, Gabriel, Banu, Shahanara, Ranasinghe, Rohan T., Broder, Graham R., Martins, Hugo F.P., Neylon, Cameron, Morgan, Hywel, Bradley, Mark and Roach, Peter L. (2007) Multistep Synthesis on SU-8: Combining Microfabrication and Solid-Phase Chemistry on a Single Material. Journal of Combinatorial Chemistry, 9, (3), 462-472. (doi:10.1021/cc060079p).
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SU-8 is an epoxy-novolac resin and a well-established negative photoresist for microfabrication and microengineering. The photopolymerized resist is an extremely highly crosslinked polymer showing outstanding chemical and physical robustness with residual surface epoxy groups amenable for chemical functionalization. In this paper we describe, for the first time, the preparation and surface modification of SU-8 particles shaped as microbars, the attachment of appropriate linkers, and the successful application of these particles to multistep solid-phase synthesis leading to oligonucleotides and peptides attached in an unambiguous manner to the support surface.
|Digital Object Identifier (DOI):||doi:10.1021/cc060079p|
|Subjects:||T Technology > TP Chemical technology
Q Science > QD Chemistry
|Divisions:||University Structure - Pre August 2011 > School of Chemistry
|Date Deposited:||27 Jun 2007|
|Last Modified:||06 Aug 2015 02:38|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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