Tests in a case-control design including relatives

Biedermann, Stefanie, Nagel, Eva, Munk, Axel, Holzmannn, Hajo and Steland, Ansgar (2006) Tests in a case-control design including relatives. Scandinavian Journal of Statistics, 33, (4), 621-635. (doi:10.1111/j.1467-9469.2006.00500.x).

This is the latest version of this item.


[img] Postscript
Download (311Kb)


We present a new approach to handle dependencies within the general framework of case-control designs, illustrating our approach by a particular application from the field of genetic epidemiology. The method is derived for parent-offspring trios, which will later be relaxed to more general family structures.
For applications in genetic epidemiology we consider tests on equality of allele frequencies among cases and controls utilizing well-known risk measures to test for independence of phenotype and genotype at the observed locus. These test statistics are derived as functions of the entries in the associated contingency table containing the numbers of the alleles under consideration in the case and the control group.
We find the joint asymptotic distribution of these entries,
which enables us to derive critical values for any test constructed on this basis. A simulation study reveals the finite sample behavior of our test statistics.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1111/j.1467-9469.2006.00500.x
ISSNs: 0303-6898 (print)
Related URLs:
Keywords: association tests, contingency tables, dependent data, risk measures
Subjects: Q Science > QA Mathematics
H Social Sciences > HA Statistics
Divisions : University Structure - Pre August 2011 > School of Mathematics > Statistics
ePrint ID: 46515
Accepted Date and Publication Date:
December 2006Published
Date Deposited: 03 Jul 2007
Last Modified: 31 Mar 2016 12:21
URI: http://eprints.soton.ac.uk/id/eprint/46515

Available Versions of this Item

Actions (login required)

View Item View Item

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics