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Bone remodelling algorithms incorporating both strain and microdamage stimuli

Bone remodelling algorithms incorporating both strain and microdamage stimuli
Bone remodelling algorithms incorporating both strain and microdamage stimuli
Biomechanical theories to predict bone remodelling have used either mechanical strain or microdamage as the stimulus driving cellular responses. Even though experimental data have implicated both stimuli in bone cell regulation, a mechano-regulatory system incorporating both stimuli has not yet been proposed. In this paper, we test the hypothesis that bone remodelling may be regulated by signals due to both strain and microdamage. Four mechano-regulation algorithms are studied where the stimulus is: strain, damage, combined strain/damage, and either strain or damage with damage-adaptive remodelling prioritised when damage is above a critical level. Each algorithm is implemented with both bone lining cell (surface) sensors and osteocyte cell (internal) sensors. Each algorithm is applied to prediction of a bone multicellular unit (BMU) remodelling on the surface of a bone trabecula. It is predicted that a regulatory system capable of responding to changes in either strain or microdamage but which prioritises removal of damaged bone when damage is above a critical level, is the only one that provides a plausible prediction of BMU behaviour. A mechanism for this may be that, below a certain damage threshold, osteocyte processes can sense changes in strain and fluid flow but above the threshold damage interferes with the signalling mechanism, or causes osteocyte apoptosis so that a remodelling response occurs to remove the dead osteocytes.
bone, remodelling, strain, microdamage, mechano-regulation, mechanobiology
0021-9290
1381-1391
McNamara, Laoise M.
8b38de74-fb61-41c9-9194-26bab1db6ef3
Prendergast, Patrcik J.
bd291125-f78b-4ddf-aac8-50d74c48a546
McNamara, Laoise M.
8b38de74-fb61-41c9-9194-26bab1db6ef3
Prendergast, Patrcik J.
bd291125-f78b-4ddf-aac8-50d74c48a546

McNamara, Laoise M. and Prendergast, Patrcik J. (2007) Bone remodelling algorithms incorporating both strain and microdamage stimuli. Journal of Biomechanics, 40 (6), 1381-1391. (doi:10.1016/j.jbiomech.2006.05.007).

Record type: Article

Abstract

Biomechanical theories to predict bone remodelling have used either mechanical strain or microdamage as the stimulus driving cellular responses. Even though experimental data have implicated both stimuli in bone cell regulation, a mechano-regulatory system incorporating both stimuli has not yet been proposed. In this paper, we test the hypothesis that bone remodelling may be regulated by signals due to both strain and microdamage. Four mechano-regulation algorithms are studied where the stimulus is: strain, damage, combined strain/damage, and either strain or damage with damage-adaptive remodelling prioritised when damage is above a critical level. Each algorithm is implemented with both bone lining cell (surface) sensors and osteocyte cell (internal) sensors. Each algorithm is applied to prediction of a bone multicellular unit (BMU) remodelling on the surface of a bone trabecula. It is predicted that a regulatory system capable of responding to changes in either strain or microdamage but which prioritises removal of damaged bone when damage is above a critical level, is the only one that provides a plausible prediction of BMU behaviour. A mechanism for this may be that, below a certain damage threshold, osteocyte processes can sense changes in strain and fluid flow but above the threshold damage interferes with the signalling mechanism, or causes osteocyte apoptosis so that a remodelling response occurs to remove the dead osteocytes.

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More information

Published date: 2007
Keywords: bone, remodelling, strain, microdamage, mechano-regulation, mechanobiology

Identifiers

Local EPrints ID: 46698
URI: http://eprints.soton.ac.uk/id/eprint/46698
ISSN: 0021-9290
PURE UUID: a8a4b24f-d984-4ea0-8885-63f7ff042895

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Date deposited: 13 Jul 2007
Last modified: 15 Mar 2024 09:26

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Contributors

Author: Laoise M. McNamara
Author: Patrcik J. Prendergast

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