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Computational modelling of cell spreading and tissue regeneration in porous scaffolds

Computational modelling of cell spreading and tissue regeneration in porous scaffolds
Computational modelling of cell spreading and tissue regeneration in porous scaffolds
Improved biological and mechanical functionality of musculoskeletal tissue-engineered constructs is required for clinical application, which can only be achieved by comprehensive multidisciplinary research. This review focuses on the contribution of computational modelling as a framework for obtaining an integrated understanding of key processes, which include: nutrient transport and utilization, matrix formation, cell population dynamics, cell attachment and migration, and local cell–cell interactions. Such an integrated perspective of these key aspects will be critical to open up new directions in tissue engineering research, as significant progress can be made by combining existing computational and experimental methods. Furthermore, theoretical modelling has enormous potential in applications ranging from the interpretation of experimental results and the identification of the main governing processes, to the optimization of practical tissue engineering protocols with implications therein for an increasing ageing population.
bone tissue engineering, cartilage tissue engineering, modelling, cell proliferation, cell spreading, extracellular matrix
0142-9612
1926-1940
Sengers, Bram G.
d6b771b1-4ede-48c5-9644-fa86503941aa
Taylor, Mark
e368bda3-6ca5-4178-80e9-41a689badeeb
Please, Colin P.
118dffe7-4b38-4787-a972-9feec535839e
Oreffo, Richard O.C.
ff9fff72-6855-4d0f-bfb2-311d0e8f3778
Sengers, Bram G.
d6b771b1-4ede-48c5-9644-fa86503941aa
Taylor, Mark
e368bda3-6ca5-4178-80e9-41a689badeeb
Please, Colin P.
118dffe7-4b38-4787-a972-9feec535839e
Oreffo, Richard O.C.
ff9fff72-6855-4d0f-bfb2-311d0e8f3778

Sengers, Bram G., Taylor, Mark, Please, Colin P. and Oreffo, Richard O.C. (2007) Computational modelling of cell spreading and tissue regeneration in porous scaffolds. Biomaterials, 28 (10), 1926-1940. (doi:10.1016/j.biomaterials.2006.12.008).

Record type: Article

Abstract

Improved biological and mechanical functionality of musculoskeletal tissue-engineered constructs is required for clinical application, which can only be achieved by comprehensive multidisciplinary research. This review focuses on the contribution of computational modelling as a framework for obtaining an integrated understanding of key processes, which include: nutrient transport and utilization, matrix formation, cell population dynamics, cell attachment and migration, and local cell–cell interactions. Such an integrated perspective of these key aspects will be critical to open up new directions in tissue engineering research, as significant progress can be made by combining existing computational and experimental methods. Furthermore, theoretical modelling has enormous potential in applications ranging from the interpretation of experimental results and the identification of the main governing processes, to the optimization of practical tissue engineering protocols with implications therein for an increasing ageing population.

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More information

Published date: April 2007
Additional Information: Review
Keywords: bone tissue engineering, cartilage tissue engineering, modelling, cell proliferation, cell spreading, extracellular matrix

Identifiers

Local EPrints ID: 47591
URI: http://eprints.soton.ac.uk/id/eprint/47591
ISSN: 0142-9612
PURE UUID: af0ab9d1-cac4-42c7-b19a-320989e74c16
ORCID for Bram G. Sengers: ORCID iD orcid.org/0000-0001-5859-6984
ORCID for Richard O.C. Oreffo: ORCID iD orcid.org/0000-0001-5995-6726

Catalogue record

Date deposited: 03 Aug 2007
Last modified: 16 Mar 2024 03:51

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Contributors

Author: Bram G. Sengers ORCID iD
Author: Mark Taylor
Author: Colin P. Please

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