Nonlinear association between CGG repeat number and age of menopause in FMR1 premutation carriers
Ennis, Sarah, Ward, Daniel and Murray, Anna (2006) Nonlinear association between CGG repeat number and age of menopause in FMR1 premutation carriers. European Journal of Human Genetics, 14, (2), 253-255. (doi:10.1038/sj.ejhg.5201510).
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FMR1 premutations are known to be associated with premature ovarian failure (POF), but the underlying mechanism is unknown. We present evidence for a nonlinear association between menopause age and premutation size suggesting that premutations in the mid-size range are at greatest risk for POF, while larger premutations are at lower risk.
|Digital Object Identifier (DOI):||doi:10.1038/sj.ejhg.5201510|
|Subjects:||R Medicine > RG Gynecology and obstetrics
Q Science > QH Natural history > QH426 Genetics
|Divisions:||University Structure - Pre August 2011 > School of Medicine > Human Genetics
|Date Deposited:||16 Aug 2007|
|Last Modified:||31 Mar 2016 12:24|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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