Nonlinear association between CGG repeat number and age of menopause in FMR1 premutation carriers


Ennis, Sarah, Ward, Daniel and Murray, Anna (2006) Nonlinear association between CGG repeat number and age of menopause in FMR1 premutation carriers. European Journal of Human Genetics, 14, (2), 253-255. (doi:10.1038/sj.ejhg.5201510).

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Original Publication URL: http://dx.doi.org/10.1038/sj.ejhg.5201510

Description/Abstract

FMR1 premutations are known to be associated with premature ovarian failure (POF), but the underlying mechanism is unknown. We present evidence for a nonlinear association between menopause age and premutation size suggesting that premutations in the mid-size range are at greatest risk for POF, while larger premutations are at lower risk.

Item Type: Article
ISSNs: 1018-4813 (print)
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Subjects: R Medicine > RG Gynecology and obstetrics
Q Science > QH Natural history > QH426 Genetics
Divisions: University Structure - Pre August 2011 > School of Medicine > Human Genetics
ePrint ID: 47963
Date Deposited: 16 Aug 2007
Last Modified: 27 Mar 2014 18:31
URI: http://eprints.soton.ac.uk/id/eprint/47963

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