Nonlinear association between CGG repeat number and age of menopause in FMR1 premutation carriers
Ennis, Sarah, Ward, Daniel and Murray, Anna (2006) Nonlinear association between CGG repeat number and age of menopause in FMR1 premutation carriers. European Journal of Human Genetics, 14, (2), 253-255. (doi:10.1038/sj.ejhg.5201510).
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Original Publication URL: http://dx.doi.org/10.1038/sj.ejhg.5201510
Description/Abstract
FMR1 premutations are known to be associated with premature ovarian failure (POF), but the underlying mechanism is unknown. We present evidence for a nonlinear association between menopause age and premutation size suggesting that premutations in the mid-size range are at greatest risk for POF, while larger premutations are at lower risk.
| Item Type: | Article |
|---|---|
| ISSNs: | 1018-4813 (print) |
| Related URLs: | |
| Subjects: | R Medicine > RG Gynecology and obstetrics Q Science > QH Natural history > QH426 Genetics |
| Divisions: | University Structure - Pre August 2011 > School of Medicine > Human Genetics |
| Item ID: | 47963 |
| Date Deposited: | 16 Aug 2007 |
| Last Modified: | 01 Jun 2011 04:46 |
| Contributors: | Ennis, Sarah (Author) Ward, Daniel (Author) Murray, Anna (Author) |
| Date: | February 2006 |
| Status: | Published |
| URI: | http://eprints.soton.ac.uk/id/eprint/47963 |
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