Embryonic cortical neural stem cells migrate ventrally and persist as postnatal striatal stem cells
Embryonic cortical neural stem cells migrate ventrally and persist as postnatal striatal stem cells
Embryonic cortical neural stem cells apparently have a transient existence, as they do not persist in the adult cortex. We sought to determine the fate of embryonic cortical stem cells by following Emx1(IREScre); LacZ/EGFP double-transgenic murine cells from midgestation into adulthood. Lineage tracing in combination with direct cell labeling and time-lapse video microscopy demonstrated that Emx1-lineage embryonic cortical stem cells migrate ventrally into the striatal germinal zone (GZ) perinatally and intermingle with striatal stem cells. Upon integration into the striatal GZ, cortical stem cells down-regulate Emx1 and up-regulate Dlx2, which is a homeobox gene characteristic of the developing striatum and striatal neural stem cells. This demonstrates the existence of a novel dorsal-to-ventral migration of neural stem cells in the perinatal forebrain.
159-168
Willaime-Morawek, S.
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Seaberg, R.M.
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Batista, C.
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Labbé, E.
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Attisano, L.
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Gorski, J.A.
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Jones, K.R.
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Morshead, C.M.
dcf1cdde-29d0-4946-a9bd-a17cae681d1d
van der Kooy, D.
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9 October 2006
Willaime-Morawek, S.
24a2981f-aa9e-4bf6-ad12-2ccf6b49f1c0
Seaberg, R.M.
dec07171-300a-404f-a693-cc51301be724
Batista, C.
60276640-10c5-4159-91ed-f88376f625e9
Labbé, E.
a1559165-afc3-432c-bbad-5f18c3132aba
Attisano, L.
6ae9bf41-25fa-4044-a394-f8d4562568ad
Gorski, J.A.
104bb5b9-0a13-4b51-92c9-52658c3c57b0
Jones, K.R.
97bda0e0-cadb-4a2b-b3fc-74e261b6ccc5
Morshead, C.M.
dcf1cdde-29d0-4946-a9bd-a17cae681d1d
van der Kooy, D.
b9a759b8-56ec-4059-9421-02337257fa16
Willaime-Morawek, S., Seaberg, R.M., Batista, C., Labbé, E., Attisano, L., Gorski, J.A., Jones, K.R., Morshead, C.M. and van der Kooy, D.
(2006)
Embryonic cortical neural stem cells migrate ventrally and persist as postnatal striatal stem cells.
Journal of Cell Biology, 175 (1), .
(doi:10.1083/jcb.200604123).
(PMID:17030986)
Abstract
Embryonic cortical neural stem cells apparently have a transient existence, as they do not persist in the adult cortex. We sought to determine the fate of embryonic cortical stem cells by following Emx1(IREScre); LacZ/EGFP double-transgenic murine cells from midgestation into adulthood. Lineage tracing in combination with direct cell labeling and time-lapse video microscopy demonstrated that Emx1-lineage embryonic cortical stem cells migrate ventrally into the striatal germinal zone (GZ) perinatally and intermingle with striatal stem cells. Upon integration into the striatal GZ, cortical stem cells down-regulate Emx1 and up-regulate Dlx2, which is a homeobox gene characteristic of the developing striatum and striatal neural stem cells. This demonstrates the existence of a novel dorsal-to-ventral migration of neural stem cells in the perinatal forebrain.
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Willaime-Morawek_JCB_2006.pdf
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Published date: 9 October 2006
Organisations:
Clinical Neurosciences
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Local EPrints ID: 48490
URI: http://eprints.soton.ac.uk/id/eprint/48490
ISSN: 1540-8140
PURE UUID: 07d5e25d-8964-45da-9ca5-3995b12b862b
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Date deposited: 26 Sep 2007
Last modified: 16 Mar 2024 03:57
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Contributors
Author:
R.M. Seaberg
Author:
C. Batista
Author:
E. Labbé
Author:
L. Attisano
Author:
J.A. Gorski
Author:
K.R. Jones
Author:
C.M. Morshead
Author:
D. van der Kooy
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