Differential effects of fatness, fitness and physical activity energy expenditure on whole-body, liver and fat insulin sensitivity
Holt, H.B., Wild, S.H., Wareham, N., Ekelund, U., Umpleby, M., Shojaee-Moradie, F., Holt, R.I.G., Phillips, D.I. and Byrne, C.D. (2007) Differential effects of fatness, fitness and physical activity energy expenditure on whole-body, liver and fat insulin sensitivity. Diabetologia, 50, (8), 1698-1706. (doi:10.1007/s00125-007-0705-1).
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AIMS/HYPOTHESIS: The relative contributions of fitness (maximal oxygen uptake), physical activity energy expenditure (PAEE) and fatness to whole-body, liver and fat insulin sensitivity is uncertain. The aim of this study was to determine whether fitness and PAEE are associated with whole-body, liver and fat insulin sensitivity independently of body fat.
MATERIALS AND METHODS: We recruited 25 men (mean [SD] age 53  years). Whole-body (M value) and liver (percentage suppression of endogenous glucose output) insulin sensitivity were estimated using a hyperinsulinaemic-euglycaemic clamp. Insulin sensitivity in fat (insulin sensitivity index for NEFA) was estimated during an OGTT. Total and truncal fat were measured by dual-energy X-ray absorptiometry, fitness by treadmill, and PAEE (n = 21) by 3 day heart rate monitoring and Baecke questionnaire.
RESULTS: In univariate analyses, fatness was strongly associated with insulin sensitivity (whole-body, liver and fat). Fitness was associated with whole-body (r = 0.53, p < 0.007) and liver (0.42, p = 0.04) insulin sensitivity, while PAEE was associated with liver insulin sensitivity (r = 0.55, p = 0.01). Regression models were established to describe associations between fatness, fitness and physical activity and measures of insulin sensitivity (whole-body, fat and liver) as outcomes. Only fatness was independently associated with whole-body insulin sensitivity (B coefficient -0.01, p = 0.001). Fitness was not associated with any outcome. Only PAEE was independently associated with liver insulin sensitivity (B coefficient 13.5, p = 0.02).
CONCLUSIONS/INTERPRETATION: Fatness explains most of the variance in whole-body insulin sensitivity. In contrast, PAEE explains most of the variance in liver insulin sensitivity.
|Digital Object Identifier (DOI):||doi:10.1007/s00125-007-0705-1|
|Keywords:||fitness, hyperinsulinaemic, euglycaemic clamp, insulin resistance, insulin sensitivity (whole-body, liver and fat), obesity (visceral, truncal and subcutaneous), PAEE, physical activity, physical activity energy expenditure|
|Subjects:||R Medicine > RB Pathology
R Medicine > RC Internal medicine > RC1200 Sports Medicine
R Medicine > RM Therapeutics. Pharmacology
|Divisions:||University Structure - Pre August 2011 > School of Medicine > Developmental Origins of Health and Disease
|Date Deposited:||27 Sep 2007|
|Last Modified:||27 Mar 2014 18:32|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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