Comparison of microfocus- and synchrotron x-ray tomography for the analysis of osteointgration around Ti6Al4V implants

Bernhardt, Ricardo, Scharnweber, Dieter, Müller, Bert, Beckmann, Felix, Thurner, Philipp J., Schliephake, Henning, Wyss, Peter, Beckmann, F., Goebbels, Juergen and Worch, Hartmut (2004) Comparison of microfocus- and synchrotron x-ray tomography for the analysis of osteointgration around Ti6Al4V implants. European Cells and Materials, 7, 42-51.


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Micro-computed tomography (µCT) provides quantitative three-dimensional information of bone around titanium implants similar to classical histology. The study, based on an animal model, using cuboid-shaped biofunctionalised Ti6Al4V implants with surrounding bone after 4 weeks, is performed using 3 µCT-systems with X-ray tubes, one synchrotron-radiation-based µCT-system (SRµCT), and classical histology. Although the spatial resolution of the µCTsystems is comparable, only the results of SRµCT agree with results of classical histology. The X-ray tube sources give rise to huge artefacts in the tomograms (interface scattering, beam hardening), which impaired the quantitative analysis of bone up to about 200 µm from the implant surface. Due to the non-destructive character of µCT the specimens can be subsequently examined by classical histology without restriction. The quantitative comparison of bone formation uncovers the strong dependence of the detected amount of newly formed bone from the selected slice. This implies the necessity of 3D analysis. SRµCT and classical histology prove that surface modifications of the titanium implant significantly influence the bone formation.

Item Type: Article
ISSNs: 1473-2262 (print)
Related URLs:
Keywords: x-ray micro computed tomography, comparison of microfocus and synchrotron radiation, osteointegration, surface modification of titanium implants, histology, bone segmentation, quantification of bone formation
Subjects: Q Science > QA Mathematics > QA75 Electronic computers. Computer science
Q Science > QH Natural history > QH301 Biology
R Medicine > RD Surgery
Divisions : University Structure - Pre August 2011 > School of Engineering Sciences > Bioengineering Sciences
ePrint ID: 48924
Accepted Date and Publication Date:
30 June 2004Published
Date Deposited: 18 Oct 2007
Last Modified: 31 Mar 2016 12:25

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