Non-destructive three-dimensional evaluation of a polymer sponge by micro-tomography using synchrotron radiation

Müller, Bert, Beckmann, Felix, Huser, Marius, Maspero, Fabrice A., Szekely, Gabor, Ruffieux, Kurt, Thurner, Philipp and Wintermantel, Erich (2002) Non-destructive three-dimensional evaluation of a polymer sponge by micro-tomography using synchrotron radiation. Biomolecular Engineering, 19, (2-6), 73-78. (doi:10.1016/S1389-0344(02)00014-X).


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X-ray micro-tomography, a non-destructive technique is used to uncover the complex 3-D micro-architecture of a degradable polymer sponge designed for bone augmentation. The measurements performed at HASYLAB at DESY are based on a synchrotron radiation source resulting in a spatial resolution of about 5.4 microm. In the present communication we report the quantitative analysis of the porosity and of the pore architecture. First, we elucidate that synchrotron radiation at the photon energy of 9 keV has an appropriate cross section for this low-weight material. Modifications in sponge micro-architecture during measurement are not detected. Second, the treatment of the data, an amount of 2.5 Gbyte to generate binary data is described. We compare the 3-D with the 2-D analysis in a quantitative manner. The obtained values for the mean distance to material within the sponge calculated from 2-D and 3-D data of the whole tomogram differ significantly: 12.5 microm for 3-D and 17.6 microm for 2-D analysis. If the pores exhibit a spherical shape as frequently found, the derived mean pore diameter, however, is overestimated only by 6% in the 2-D image analysis with respect to the 3-D evaluation. This approach can be applied to different porous biomaterials and composites even in a hydrated state close to physiological conditions, where any surface preparation artifact is avoided.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1016/S1389-0344(02)00014-X
ISSNs: 1389-0344 (print)
Related URLs:
Keywords: biodegradable scaffold, X-ray microtomography, synchrotron radiation, three-dimensional image analysis, porosity
Subjects: T Technology > TA Engineering (General). Civil engineering (General)
Q Science > QH Natural history > QH301 Biology
Divisions : University Structure - Pre August 2011 > School of Engineering Sciences > Bioengineering Sciences
ePrint ID: 48954
Accepted Date and Publication Date:
August 2002Published
Date Deposited: 18 Oct 2007
Last Modified: 31 Mar 2016 12:25

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