A dominant bursting electromyograph pattern in dystonic conditions predicts an early response to pallidal stimulation

Yianni, John, Wang, Shou Yan, Liu, Xuguang, Bain, Peter G., Nandi, Dipankar, Gregory, Ralph, Joint, Carole, Stein, John F. and Aziz, Tipu Z. (2006) A dominant bursting electromyograph pattern in dystonic conditions predicts an early response to pallidal stimulation. Journal of Clinical Neuroscience, 13, (7), 738-746. (doi:10.1016/j.jocn.2005.07.022).


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Although chronic pallidal deep brain stimulation (DBS) is effective in the treatment of medically intractable dystonia, there is no way of predicting the variations in clinical outcome, partly due to our limited understanding of the pathophysiological mechanisms underlying this condition. We recorded electromyographic (EMG) activity from the most severely affected muscle groups in seven dystonia patients before and after pallidal DBS. Patient EMG recordings could be classified into two groups: one consisting of patients who at rest demonstrated a dominant low frequency component of activity on power spectral analysis (ranging from 2 to 5 Hz), and one group in which this dominant pattern was absent. Early postoperative improvements (within 2–3 days) were observed in the former group, whereas the latter group benefited more gradually (over several months). Analysis of EMG activity may provide a sensitive means of identifying dystonic patients who are likely to be most responsive to functional neurosurgical intervention.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1016/j.jocn.2005.07.022
Additional Information:
ISSNs: 0967-5868 (print)
Related URLs:
Keywords: dystonia, EMG, pallidum, stimulation
Subjects: R Medicine > RZ Other systems of medicine
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
T Technology > TA Engineering (General). Civil engineering (General)
Q Science > QC Physics
Divisions : University Structure - Pre August 2011 > Institute of Sound and Vibration Research > Human Sciences
ePrint ID: 49596
Accepted Date and Publication Date:
August 2006Published
Date Deposited: 21 Nov 2007
Last Modified: 31 Mar 2016 12:26
URI: http://eprints.soton.ac.uk/id/eprint/49596

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