The physiologically modulated electrode potentials at the depth electrode-brain interface in humans

Xie, K., Wang, S., Aziz, T.Z., Stein, J.F. and Liu, X. (2006) The physiologically modulated electrode potentials at the depth electrode-brain interface in humans. Neuroscience Letters, 402, (3), 238-243. (doi:10.1016/j.neulet.2006.04.015).


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To study the modulated electrical potential specifically related to the electrode–brain interface (EBI) in deep brain stimulation (DBS) under physiological condition, we quantitatively identified the physiologically modulated electrode potentials by decomposing the local field potentials (LFPs) recorded from 11 patients (18 electrodes in four different brain regions) who underwent DBS, and correlated them with simultaneously recorded physiological signals of blood pressure (BP) and respiration. Results showed that electrode potentials were modulated by BP and respiration and could be detected as a specific component of the compound LFP signals with a mean (±S.D.) amplitude of 6.9 ± 1.7 ?V. The detection rate and amplitude of the modulated electrode potentials were independent from brain regions and neurological disorders. The current approach can be used to study the changes in properties of the EBI under physiological condition and to investigate the effects of the EBI on the ‘crossing’ current of either the neural signals to be recorded or the electrical pulses for neurostimulation.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1016/j.neulet.2006.04.015
Additional Information:
ISSNs: 0304-3940 (print)
Related URLs:
Keywords: deep brain stimulation, electrode potentials, local field potentials, brain pulsation, electrode–brain interface
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
R Medicine > RV Botanic, Thomsonian, and eclectic medicine
T Technology > TA Engineering (General). Civil engineering (General)
Divisions : University Structure - Pre August 2011 > Institute of Sound and Vibration Research > Human Sciences
ePrint ID: 49597
Accepted Date and Publication Date:
24 July 2006Published
Date Deposited: 21 Nov 2007
Last Modified: 31 Mar 2016 12:26

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