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Intelligence in DSM-IV combined type attention-deficit/hyperactivity disorder is not predicted by either dopamine receptor/transporter genes or other previously identified risk alleles for attention-deficit/hyperactivity disorder

Intelligence in DSM-IV combined type attention-deficit/hyperactivity disorder is not predicted by either dopamine receptor/transporter genes or other previously identified risk alleles for attention-deficit/hyperactivity disorder
Intelligence in DSM-IV combined type attention-deficit/hyperactivity disorder is not predicted by either dopamine receptor/transporter genes or other previously identified risk alleles for attention-deficit/hyperactivity disorder
A major goal of genetic studies of attention deficit hyperactivity disorder (ADHD) is to identify individual characteristics that might help segregate the disorder's inherent heterogeneity. [Mill et al. (2006); Arch Ger Psychiatry 63:462-469] recently reported a potentially important association between two dopamine-related risk polymorphisms (DRD4 variable number tandem repeat (VNTR) in exon 3 and DAT1 VNTR in the 3 UTR) and lowered IQ in ADHD. The objective of the current study was to replicate the [Mill et al. (2006); Arch Ger Psychiatry 63:462-469] findings in a clinical sample and to extend the analysis to a large range of alternative SNP markers of putative ADHD risk alleles identified in a recent study [Brookes et al. (2006); Mol Genet 11:934-953]. Participants were 1081 children and adolescents with a research-confirmed combined type ADHD diagnosis and 1300 unaffected siblings who took part in the International Multi-centre ADHD Genetics (IMAGE) project. They were recruited from multiple settings from across Europe: Belgium, Britain, Germany, Ireland, Israel, Netherlands, Spain and Switzerland. The results were that ADHD was associated with reduced IQ. However, there was no association between the two dopamine-related risk polymorphisms and IQ in either the probands or their siblings. Furthermore, other selected genetic markers previously demonstrated to be associated with ADHD in this sample were not associated with IQ. This large scale study with a clinically ascertained and regorously diagnosed sample failed to replicate the association between genetic polymorphisms in the dopamine system and IQ in ADHD. We also observed no association of other SNPs with IQ in ADHD.
adhd, dopamine, iq, image, genetics
1552-4841
316-319
Sonuga-Barke, Edmund J.S.
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Brookes, Keeley-Joanne
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Buitelaar, Jan
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Anney, Richard
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Bitsakou, Paraskevi
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Baeyens, Dieter
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Buschgens, Cathelijne
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Chen, Wai
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Christiansen, Hanna
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Eisenberg, Jacques
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Kuntsi, Jonna
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Manor, Iris
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Meliá, Amanda
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Mulligan, Aisling
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Rommelse, Nanda
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Muller, Ueli C.
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Uebel, Henrik
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Banaschewski, Tobias
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Ebstein, Richard
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Franke, Barbara
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Gill, Michael
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Miranda, Ana
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Oades, Robert D.
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Roeyers, Herbert
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Rothenberger, Aribert
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Sergeant, Joseph
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Steinhausen, Hans Christoph
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Thompson, Margaret
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Taylor, Eric
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Asherson, Philip
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Faraone, Stephen V.
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Sonuga-Barke, Edmund J.S.
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Brookes, Keeley-Joanne
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Buitelaar, Jan
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Anney, Richard
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Bitsakou, Paraskevi
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Baeyens, Dieter
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Buschgens, Cathelijne
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Chen, Wai
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Christiansen, Hanna
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Eisenberg, Jacques
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Kuntsi, Jonna
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Manor, Iris
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Meliá, Amanda
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Mulligan, Aisling
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Rommelse, Nanda
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Muller, Ueli C.
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Uebel, Henrik
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Banaschewski, Tobias
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Ebstein, Richard
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Franke, Barbara
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Gill, Michael
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Miranda, Ana
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Oades, Robert D.
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Roeyers, Herbert
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Rothenberger, Aribert
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Sergeant, Joseph
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Steinhausen, Hans Christoph
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Thompson, Margaret
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Taylor, Eric
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Asherson, Philip
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Faraone, Stephen V.
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Sonuga-Barke, Edmund J.S., Brookes, Keeley-Joanne, Buitelaar, Jan, Anney, Richard, Bitsakou, Paraskevi, Baeyens, Dieter, Buschgens, Cathelijne, Chen, Wai, Christiansen, Hanna, Eisenberg, Jacques, Kuntsi, Jonna, Manor, Iris, Meliá, Amanda, Mulligan, Aisling, Rommelse, Nanda, Muller, Ueli C., Uebel, Henrik, Banaschewski, Tobias, Ebstein, Richard, Franke, Barbara, Gill, Michael, Miranda, Ana, Oades, Robert D., Roeyers, Herbert, Rothenberger, Aribert, Sergeant, Joseph, Steinhausen, Hans Christoph, Thompson, Margaret, Taylor, Eric, Asherson, Philip and Faraone, Stephen V. (2008) Intelligence in DSM-IV combined type attention-deficit/hyperactivity disorder is not predicted by either dopamine receptor/transporter genes or other previously identified risk alleles for attention-deficit/hyperactivity disorder. American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, 147B, 316-319. (doi:10.1002/ajmg.b.30596).

Record type: Article

Abstract

A major goal of genetic studies of attention deficit hyperactivity disorder (ADHD) is to identify individual characteristics that might help segregate the disorder's inherent heterogeneity. [Mill et al. (2006); Arch Ger Psychiatry 63:462-469] recently reported a potentially important association between two dopamine-related risk polymorphisms (DRD4 variable number tandem repeat (VNTR) in exon 3 and DAT1 VNTR in the 3 UTR) and lowered IQ in ADHD. The objective of the current study was to replicate the [Mill et al. (2006); Arch Ger Psychiatry 63:462-469] findings in a clinical sample and to extend the analysis to a large range of alternative SNP markers of putative ADHD risk alleles identified in a recent study [Brookes et al. (2006); Mol Genet 11:934-953]. Participants were 1081 children and adolescents with a research-confirmed combined type ADHD diagnosis and 1300 unaffected siblings who took part in the International Multi-centre ADHD Genetics (IMAGE) project. They were recruited from multiple settings from across Europe: Belgium, Britain, Germany, Ireland, Israel, Netherlands, Spain and Switzerland. The results were that ADHD was associated with reduced IQ. However, there was no association between the two dopamine-related risk polymorphisms and IQ in either the probands or their siblings. Furthermore, other selected genetic markers previously demonstrated to be associated with ADHD in this sample were not associated with IQ. This large scale study with a clinically ascertained and regorously diagnosed sample failed to replicate the association between genetic polymorphisms in the dopamine system and IQ in ADHD. We also observed no association of other SNPs with IQ in ADHD.

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Published date: 2008
Keywords: adhd, dopamine, iq, image, genetics

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Local EPrints ID: 50137
URI: http://eprints.soton.ac.uk/id/eprint/50137
ISSN: 1552-4841
PURE UUID: 95a28f0d-a7c0-4c78-a73a-82c9b42bd19d

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Date deposited: 30 Jan 2008
Last modified: 15 Mar 2024 10:03

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Contributors

Author: Edmund J.S. Sonuga-Barke
Author: Keeley-Joanne Brookes
Author: Jan Buitelaar
Author: Richard Anney
Author: Paraskevi Bitsakou
Author: Dieter Baeyens
Author: Cathelijne Buschgens
Author: Wai Chen
Author: Hanna Christiansen
Author: Jacques Eisenberg
Author: Jonna Kuntsi
Author: Iris Manor
Author: Amanda Meliá
Author: Aisling Mulligan
Author: Nanda Rommelse
Author: Ueli C. Muller
Author: Henrik Uebel
Author: Tobias Banaschewski
Author: Richard Ebstein
Author: Barbara Franke
Author: Michael Gill
Author: Ana Miranda
Author: Robert D. Oades
Author: Herbert Roeyers
Author: Aribert Rothenberger
Author: Joseph Sergeant
Author: Hans Christoph Steinhausen
Author: Margaret Thompson
Author: Eric Taylor
Author: Philip Asherson
Author: Stephen V. Faraone

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