Optimisation of analyte transport in integrated microfluidic affinity sensors for the quantification of low levels of analyte
Friedrich, Daniel, Please, Colin P. and Melvin, Tracy (2008) Optimisation of analyte transport in integrated microfluidic affinity sensors for the quantification of low levels of analyte. Sensors and Actuators B: Chemical, 131, (1), 323-332. (doi:10.1016/j.snb.2007.11.034).
New designs for microfluidic channels to be integrated with small-scale affinity sensors for analytical applications are provided. Theoretical approaches demonstrate efficient and uniform mass transfer of the analyte from the bulk flow to small-scale affinity sensors in the base of fluidic channels by (i) active control of the analyte flow speed over the affinity sensor, (ii) non-rectangular channel geometries and (iii) non-uniform distributions of recognition binding sites over the active area of the sensor. The methodology reported provides generic strategies that can be exploited for small-scale sensors in single or multiplex formats.
|Keywords:||affinity sensor, microfluidics, mass transfer, laminar flow, biosensor, fluidic channel, detection, design optimisation, recognition molecule, analyte depletion|
|Subjects:||Q Science > QA Mathematics
T Technology > TP Chemical technology
|Divisions:||University Structure - Pre August 2011 > School of Mathematics
University Structure - Pre August 2011 > Optoelectronics Research Centre
|Date Deposited:||09 Jun 2008|
|Last Modified:||29 May 2014 15:21|
OPTICAL WAVEGUIDE SENSORS FOR HIGHLY SENSITIVE DETECTION & QUANTIFICATION OF CYTOKINES IN BIOLOGICAL FLUIDS
Funded by: BBSRC (BB/D014476/1)
Led by: Tracy Melvin
1 July 2007 to 31 December 2008
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