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G72 and its association with major depression and neuroticism in large population-based groups from Germany

G72 and its association with major depression and neuroticism in large population-based groups from Germany
G72 and its association with major depression and neuroticism in large population-based groups from Germany
OBJECTIVE: G72 is among the most frequently replicated vulnerability genes for schizophrenia and bipolar disorder. The authors previously found identical haplotypes of markers M23 and M24 to be associated with schizophrenia, bipolar disorder, and panic disorder. Given both the well-recognized familial clustering across these disorders and recent linkage findings implicating the region harboring G72 in the etiology of major depression and panic disorder, we can hypothesize that G72 should also be involved in the etiology of major depression. Neuroticism, measuring trait anxiety, may be the endophenotypic link underlying genetic associations with G72 across diagnostic boundaries. The authors tested whether the previously observed risk haplotypes are also associated with major depression and neuroticism. METHOD: The authors performed a standard haplotype analysis in a group of 500 major depression patients and 1,030 population-based comparison subjects. The authors also performed an exploratory analysis on 10 additional G72 markers using a novel haplotype-sharing approach. They performed a quantitative trait haplotype analysis in an independent group of 907 individuals phenotyped for neuroticism. RESULTS: The previously identified M23-M24 risk haplotype was significantly associated with major depression and high levels of neuroticism. The haplotype-sharing analysis also implicated the same region, whereas more proximal markers showed no association with major depression. CONCLUSIONS: This is the first study to the authors’ knowledge to implicate the G72 locus in the etiology of major depression and neuroticism. The results strengthen the notion of a genetic overlap between diagnoses, commonly conceptualized as distinct entities. Neuroticism may constitute the common underlying endophenotypic link.
1535-7228
753-762
Rietschel, Marcella
bfe692f6-8ff2-4137-aa33-b28b65710390
Beckmann, Lars
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Strohmeier, Jana
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Georgi, Alexander
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Karpushova, Anna
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Schirmbeck, Frederike
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Boesshenz, Katja
601c4158-468f-471b-928d-9a63a111bffb
Schmäl, Christine
c554b903-d2ee-4d82-a8a0-0407406e8d04
Bürger, Christin
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Jamra, Rami Abou
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Schumacher, Johannes
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Höfels, Susanne
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Kumsta, Robert
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Entringer, Sonja
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Krug, Axel
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Markov, Valentin
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Maier, Wolfgang
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Propping, Peter
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Wüst, Stefan
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Kircher, Tilo
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Nöthen, Markus
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Cichon, Sven
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Schulze, Thomas
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Rietschel, Marcella
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Beckmann, Lars
58b386ec-20fe-4ffe-a16e-3813361fa8e2
Strohmeier, Jana
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Georgi, Alexander
20f29e49-c4c6-4f0d-a8c4-8213320ad172
Karpushova, Anna
7bbc4353-98fb-4712-b178-9baa7d832753
Schirmbeck, Frederike
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Boesshenz, Katja
601c4158-468f-471b-928d-9a63a111bffb
Schmäl, Christine
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Bürger, Christin
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Jamra, Rami Abou
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Schumacher, Johannes
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Höfels, Susanne
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Kumsta, Robert
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Entringer, Sonja
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Krug, Axel
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Markov, Valentin
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Maier, Wolfgang
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Propping, Peter
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Wüst, Stefan
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Kircher, Tilo
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Nöthen, Markus
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Cichon, Sven
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Schulze, Thomas
cbbdc13d-e1a4-4507-8909-0adf6305a1e1

Rietschel, Marcella, Beckmann, Lars, Strohmeier, Jana, Georgi, Alexander, Karpushova, Anna, Schirmbeck, Frederike, Boesshenz, Katja, Schmäl, Christine, Bürger, Christin, Jamra, Rami Abou, Schumacher, Johannes, Höfels, Susanne, Kumsta, Robert, Entringer, Sonja, Krug, Axel, Markov, Valentin, Maier, Wolfgang, Propping, Peter, Wüst, Stefan, Kircher, Tilo, Nöthen, Markus, Cichon, Sven and Schulze, Thomas (2008) G72 and its association with major depression and neuroticism in large population-based groups from Germany. American Journal of Psychiatry, 165, 753-762. (doi:10.1176/appi.ajp.2008.07060883).

Record type: Article

Abstract

OBJECTIVE: G72 is among the most frequently replicated vulnerability genes for schizophrenia and bipolar disorder. The authors previously found identical haplotypes of markers M23 and M24 to be associated with schizophrenia, bipolar disorder, and panic disorder. Given both the well-recognized familial clustering across these disorders and recent linkage findings implicating the region harboring G72 in the etiology of major depression and panic disorder, we can hypothesize that G72 should also be involved in the etiology of major depression. Neuroticism, measuring trait anxiety, may be the endophenotypic link underlying genetic associations with G72 across diagnostic boundaries. The authors tested whether the previously observed risk haplotypes are also associated with major depression and neuroticism. METHOD: The authors performed a standard haplotype analysis in a group of 500 major depression patients and 1,030 population-based comparison subjects. The authors also performed an exploratory analysis on 10 additional G72 markers using a novel haplotype-sharing approach. They performed a quantitative trait haplotype analysis in an independent group of 907 individuals phenotyped for neuroticism. RESULTS: The previously identified M23-M24 risk haplotype was significantly associated with major depression and high levels of neuroticism. The haplotype-sharing analysis also implicated the same region, whereas more proximal markers showed no association with major depression. CONCLUSIONS: This is the first study to the authors’ knowledge to implicate the G72 locus in the etiology of major depression and neuroticism. The results strengthen the notion of a genetic overlap between diagnoses, commonly conceptualized as distinct entities. Neuroticism may constitute the common underlying endophenotypic link.

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Submitted date: 5 June 2007
Published date: 17 March 2008

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Local EPrints ID: 54117
URI: http://eprints.soton.ac.uk/id/eprint/54117
ISSN: 1535-7228
PURE UUID: 57cf1796-ecd8-4a49-b6eb-7a1217e47289

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Date deposited: 29 Jul 2008
Last modified: 15 Mar 2024 10:45

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Contributors

Author: Marcella Rietschel
Author: Lars Beckmann
Author: Jana Strohmeier
Author: Alexander Georgi
Author: Anna Karpushova
Author: Frederike Schirmbeck
Author: Katja Boesshenz
Author: Christine Schmäl
Author: Christin Bürger
Author: Rami Abou Jamra
Author: Johannes Schumacher
Author: Susanne Höfels
Author: Robert Kumsta
Author: Sonja Entringer
Author: Axel Krug
Author: Valentin Markov
Author: Wolfgang Maier
Author: Peter Propping
Author: Stefan Wüst
Author: Tilo Kircher
Author: Markus Nöthen
Author: Sven Cichon
Author: Thomas Schulze

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