A new approach to the design of heterogeneous single-site enantioselective catalysts

Jones, Matthew D., Raja, Robert, Thomas, John Meurig and Johnson, Brian F.G. (2003) A new approach to the design of heterogeneous single-site enantioselective catalysts. Topics in Catalysis, 25, (1-4), 71-79. (doi:10.1023/B:TOCA.0000003099.40587.3a).


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We analyze the merits of an approach to the design of enantioselective catalysts that relies on constraining an anchored organometallic complex at the inner walls of mesoporous silica. Two distinct metal centers {Rh(I) and Pd(II)}, three distinct diamino ligands {(S)-(-)-2-aminomethyl-1-ethylpyrrolidine, (AMP), (S)-(+)-(2-pyrrolidinyl-methyl)pyrrolidine, (PMP), and (1R,2R)-(+)-1,2-diphenylethylenediamine, (DED)}, two distinct methods of anchoring (a covalent and a noncovalent one), and two specific examples of enantioselective hydrogenation (the asymmetric hydrogenation of the C=C bond in E--phenylcinnamic acid and the asymmetric hydrogenation of the C=O bond in methyl benzoylformate) have been investigated. Values of enantiomeric excess (ee) ranging from a low of 66 to a high of 93 have been achieved by this approach. Moreover, the catalysts are robust and stand up well to recycling.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1023/B:TOCA.0000003099.40587.3a
ISSNs: 1022-5528 (print)
Related URLs:
Keywords: platinum, mesoporous silica, molecular-sieves, diamine ligands, hydrogenation, performance, surfaces, heterogeneous, mesoporous silica, asymmetric catalysis, concavity, asymmetric hydrogenation, chiral catalysts, step
Subjects: Q Science
Q Science > QD Chemistry
Divisions : University Structure - Pre August 2011 > School of Chemistry
ePrint ID: 54169
Accepted Date and Publication Date:
November 2003Published
Date Deposited: 29 Jul 2008
Last Modified: 31 Mar 2016 12:33
URI: http://eprints.soton.ac.uk/id/eprint/54169

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