Porphyrin-DNA: a supramolecular scaffold for functional molecules on the nanometre scale

Bouamaied, Imenne, Fendt, Leslie-Anne, Häussinger, Daniel, Wiesner, Markus, Thöni, Sandra, Amiot, Nicolas and Stulz, Eugen (2007) Porphyrin-DNA: a supramolecular scaffold for functional molecules on the nanometre scale. Nucleosides, Nucleotides & Nucleic Acids, 26 (10-12), 1533-1538. (doi:10.1080/15257770701544468).

Abstract

We are pursuing the aim to use DNA as a supramolecular scaffold for the creation of electronically functional molecules on the nanometre scale. Here, we give a review on our results on porphyrin modified nucleotides used for this purpose. A general synthetic route to porphyrin-nucleotides has been devised, and the building blocks can be incorporated into oligonucleotides using standard solid phase synthesis methods. Up to 11 porphyrins were incorporated into DNA, reaching a length of approximately 4 nm in the array. The spectroscopic data are consistent with a porphyrin induced secondary structure stabilisation in the single strands.

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Contributors

Author: Eugen Stulz

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