Multistep synthesis on SU-8: Combining microfabrication and solid-phase chemistry on a single material


Cavalli, G., Banu, S., Ranasinghe, R.T., Broder, G.R., Martins, H.F.P., Neylon, C., Morgan, H., Bradley, M. and Roach, P.L. (2007) Multistep synthesis on SU-8: Combining microfabrication and solid-phase chemistry on a single material. Journal of Combinatorial Chemistry, 9, (3), 462-472. (doi:10.1021/cc060079p).

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Original Publication URL: http://dx.doi.org/10.1021/cc060079p

Description/Abstract

SU-8 is an epoxy-novolac resin and a well-established negative photoresist for microfabrication and microengineering. The photopolymerized resist is an extremely highly crosslinked polymer showing outstanding chemical and physical robustness with residual surface epoxy groups amenable for chemical functionalization. In this paper we describe, for the first time, the preparation and surface modification of SU-8 particles shaped as microbars, the attachment of appropriate linkers, and the successful application of these particles to multistep solid-phase synthesis leading to oligonucleotides and peptides attached in an unambiguous manner to the support surface.

Item Type: Article
ISSNs: 1520-4766 (print)
Related URLs:
Keywords: photoresist, oligonucleotides, immobilization, capillary-electrophoresis,high-aspect-ratio, archip epoxy, , , mass-spectrometry, peptide-synthesis, protease inhibitors, mems
Subjects: Q Science
Q Science > QD Chemistry
Divisions: University Structure - Pre August 2011 > School of Chemistry
ePrint ID: 54261
Date Deposited: 31 Jul 2008
Last Modified: 28 Mar 2014 15:17
Research Funder: EPSRC
Projects:
Unknown (GR/S23513/01)
Funded by: EPSRC (GR/S23513/01)
UNSPECIFIED to UNSPECIFIED
URI: http://eprints.soton.ac.uk/id/eprint/54261

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