Regioselective synthesis of 4 '-amino-1 ' H-spiro[cyclohexane-1,2 '-(pyrimido [1,2-albenzimidazole)]-3 '-carbonitrile in aqueous medium
Dandia, A., Sarawgi, P., Bingham, A.L., Drake, J.E., Hursthouse, M.B., Light, M.E. and Ratnani, R. (2007) Regioselective synthesis of 4 '-amino-1 ' H-spiro[cyclohexane-1,2 '-(pyrimido [1,2-albenzimidazole)]-3 '-carbonitrile in aqueous medium. Journal of Chemical Research-S, S, (3), 155-159. (doi:10.3184/030823407X198582).
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Description/Abstract
A simple, mild and environment-friendly procedure for synthesis of 4'-amino-1'H-spiro[cyclohexane-1,2'-(pyrimido[1,2-a]benzimidazole)]-3'-carbonitrile is developed using microwave irradiation in water. The product is obtained in short time, in excellent yield, and in a good state of purity. The reaction pathway and the influence of reaction conditions on regiochemistry are also investigated. The regioselectivity in this process is confirmed chemically and by single-crystal X-ray molecular structure determination.
| Item Type: | Article |
|---|---|
| ISSNs: | 0308-2342 (print) |
| Related URLs: | |
| Keywords: | fused pyrimidines, aqueous media, benzimidazoles, 2-aminobenzimidazole derivatives, biological importance, crystal-structure, synthesis, green chemical-synthesis, microwave irradiation, heterocyclic, part 5, combinatorial library, , microwave irradiation, efficient, one-pot synthesis |
| Subjects: | Q Science Q Science > QD Chemistry |
| Divisions: | University Structure - Pre August 2011 > School of Chemistry |
| Item ID: | 54277 |
| Date Deposited: | 31 Jul 2008 |
| Last Modified: | 01 Jun 2011 12:03 |
| Contributors: | Dandia, A. (Author) Sarawgi, P. (Author) Bingham, A.L. (Author) Drake, J.E. (Author) Hursthouse, M.B. (Author) Light, M.E. (Author) Ratnani, R. (Author) |
| Date: | 2007 |
| Status: | Published |
| URI: | http://eprints.soton.ac.uk/id/eprint/54277 |
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