Photoinduced crosslinking of double-helical DNA by psoralen covalently linked to a triple helix-forming oligonucleotide under near-physiological conditions
Li, Hong, Broughton-Head, Victoria J., Fox, Keith R. and Brown, Tom (2007) Photoinduced crosslinking of double-helical DNA by psoralen covalently linked to a triple helix-forming oligonucleotide under near-physiological conditions. Nucleosides, Nucleotides and Nucleic Acids, 26, (8 & 9), 1005-1009. (doi:10.1080/15257770701508554).
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Description/Abstract
Stable triplexes have been generated under near-physiological conditions by the introduction of the C and T base analogues 3-methyl-2-aminopyridine-2 '-deoxyriboside and 5-(3-aminoprop-2-ynyl)-'-deoxyuridine into psoralen-conjugated triplex-forming oligonucleotides. After irradiation with UV light at 365 nm, photo-induced cross-linking of the TFO to double-helical DNA was observed by UV-melting analysis and fluorescence measurements.
| Item Type: | Article |
|---|---|
| ISSNs: | 1525-7770 (print) |
| Related URLs: | |
| Keywords: | psoralen, triplex, nucleosides, 2-aminopyridine, crosslinking |
| Subjects: | Q Science > QD Chemistry Q Science > QH Natural history > QH426 Genetics Q Science > QH Natural history > QH301 Biology |
| Divisions: | University Structure - Pre August 2011 > School of Biological Sciences University Structure - Pre August 2011 > School of Chemistry |
| Item ID: | 54336 |
| Date Deposited: | 30 Jul 2008 |
| Last Modified: | 23 Jul 2012 10:43 |
| Contributors: | Li, Hong (Author) Broughton-Head, Victoria J. (Author) Fox, Keith R. (Author) Brown, Tom (Author) |
| Date: | August 2007 |
| Status: | Published |
| URI: | http://eprints.soton.ac.uk/id/eprint/54336 |
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