Facile, one-step production of niacin (Vitamin B-3) and other nitrogen-containing pharmaceutical chemicals with a single-site heterogeneous catalyst
Raja, Robert, Thomas, John Meurig, Greenhill-Hooper, Michael, Ley, Steven V. and Paz, Filipe A. Almeida (2008) Facile, one-step production of niacin (Vitamin B-3) and other nitrogen-containing pharmaceutical chemicals with a single-site heterogeneous catalyst. Chemistry - A European Journal, 14, (8), 2340-2348. (doi:10.1002/chem.200701679).
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Description/Abstract
Niacin (3-picolinic acid), which is extensively used as vitamin B3 in foodstuffs and as a cholesterol-lowering agent, along with other oxygenated products of the picolines, 4-methylquinoline, and a variety of pyrimidines and pyridazines, may be produced in a single-step, environmentally benign fashion by combining single-site, open-structure, heterogeneous catalysts with a solid source of active oxygen, namely acetyl peroxyborate (APB), in the absence of an organic solvent. The high activities, selectivities, and the relatively mild conditions employed with this single-site heterogeneous catalyst, coupled with ease of transport, storage, and stability of the solid oxidant, augurs well for the future use of APB in conjunction with other open-structure, single-site catalysts for fine-chemical, pharmaceutical, and agrochemical applications.
| Item Type: | Article |
|---|---|
| ISSNs: | 0947-6539 (print) |
| Related URLs: | |
| Keywords: | oxidation, system, design, selective oxidation, cyclohexane, adipic acid, mesoporous materials, heterogeneous catalysis, chemistry, performance,acetyl peroxyborate green, solids |
| Subjects: | Q Science Q Science > QD Chemistry |
| Divisions: | University Structure - Pre August 2011 > School of Chemistry |
| Item ID: | 54497 |
| Date Deposited: | 19 Aug 2008 |
| Last Modified: | 01 Jun 2011 04:49 |
| Contributors: | Raja, Robert (Author) Thomas, John Meurig (Author) Greenhill-Hooper, Michael (Author) Ley, Steven V. (Author) Paz, Filipe A. Almeida (Author) |
| Date: | 28 January 2008 |
| Status: | Published |
| URI: | http://eprints.soton.ac.uk/id/eprint/54497 |
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