Facile, one-step production of niacin (Vitamin B-3) and other nitrogen-containing pharmaceutical chemicals with a single-site heterogeneous catalyst


Raja, Robert, Thomas, John Meurig, Greenhill-Hooper, Michael, Ley, Steven V. and Paz, Filipe A. Almeida (2008) Facile, one-step production of niacin (Vitamin B-3) and other nitrogen-containing pharmaceutical chemicals with a single-site heterogeneous catalyst. Chemistry - A European Journal, 14, (8), 2340-2348. (doi:10.1002/chem.200701679).

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Original Publication URL: http://dx.doi.org/10.1002/chem.200701679

Description/Abstract

Niacin (3-picolinic acid), which is extensively used as vitamin B3 in foodstuffs and as a cholesterol-lowering agent, along with other oxygenated products of the picolines, 4-methylquinoline, and a variety of pyrimidines and pyridazines, may be produced in a single-step, environmentally benign fashion by combining single-site, open-structure, heterogeneous catalysts with a solid source of active oxygen, namely acetyl peroxyborate (APB), in the absence of an organic solvent. The high activities, selectivities, and the relatively mild conditions employed with this single-site heterogeneous catalyst, coupled with ease of transport, storage, and stability of the solid oxidant, augurs well for the future use of APB in conjunction with other open-structure, single-site catalysts for fine-chemical, pharmaceutical, and agrochemical applications.

Item Type: Article
ISSNs: 0947-6539 (print)
Related URLs:
Keywords: oxidation, system, design, selective oxidation, cyclohexane, adipic acid, mesoporous materials, heterogeneous catalysis, chemistry, performance,acetyl peroxyborate green, solids
Subjects: Q Science
Q Science > QD Chemistry
Divisions: University Structure - Pre August 2011 > School of Chemistry
ePrint ID: 54497
Date Deposited: 19 Aug 2008
Last Modified: 27 Mar 2014 18:37
URI: http://eprints.soton.ac.uk/id/eprint/54497

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