Long-acting medications for the hyperkinetic disorders A systematic review and European treatment guideline

Banaschewski, Tobias, Coghill, David, Santosh, Paramala, Zuddas, Alessandro, Asherson, Philip, Buitelaar, Jan, Danckaerts, Marina, Döpfner, Manfred, Faraone, Stephen. V., Rothenberger, Aribert, Sergeant, Joseph, Steinhausen, Hans-Christoph, Sonuga-Barke, Edmund.J.S. and Taylor, Eric (2006) Long-acting medications for the hyperkinetic disorders A systematic review and European treatment guideline. European Child & Adolescent Psychiatry, 15 (8), 476-495. (doi:10.1007/s00787-006-0549-0).

Abstract

A systematic review of published and unpublished data on the use of long-acting medications in ADHD and hyperkinetic disorder is reported, giving effect sizes and numbers-to-treat for extended-release stimulant preparations and atomoxetine (ATX). A panel of experts from several European countries used the review to make recommendations about the use of these drugs in practice, and conclusions are reported: (1) Long-acting preparations should be available and used; (2) They should not replace short-acting drugs (which will be the initial treatment for many children for reasons of cost and flexibility of dosing). Individual clinical choice is needed. (3) Both ATX and extended-release preparations of stimulants should be available. The choice will depend upon the circumstances, and detailed recommendations are made.

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