Uniformly balanced repeated measurements designs in the presence of subject dropout


Majumdar, D., Dean, A.M. and Lewis, S.M. (2008) Uniformly balanced repeated measurements designs in the presence of subject dropout. Statistica Sinica, 18, (1), 235-253.

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Description/Abstract

Low, Lewis and Prescott (1999) showed that a crossover design based on a Williams Latin square of order can suffer substantial loss of efficiency if some observations in the final period are unavailable. Indeed, if all observations are missing, the design becomes disconnected. We derive the information matrix for the direct effects of a Uniformly Balanced Repeated Measurements Design (UBRMD) in periods when subjects may drop out before the end of the study, and examine the maximum loss of information. The special case of loss of observations in the final period only is examined in detail. In particular we show that a UBRMD in periods remains connected when some or all observations in the final period are unavailable.

Item Type: Article
ISSNs: 1017-0405 (print)
Related URLs:
Keywords: crossover designs, efficiency, missing observations, Williams Latin Squares
Subjects: Q Science > QA Mathematics
H Social Sciences > HA Statistics
Divisions: University Structure - Pre August 2011 > Southampton Statistical Sciences Research Institute
University Structure - Pre August 2011 > School of Mathematics > Statistics
ePrint ID: 54763
Date Deposited: 04 Aug 2008
Last Modified: 27 Mar 2014 18:37
Contact Email Address: s.m.lewis@soton.ac.uk
URI: http://eprints.soton.ac.uk/id/eprint/54763

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