The University of Southampton
University of Southampton Institutional Repository

Genetic heterogeneity in ADHD: DAT1 gene only affects probands without CD

Genetic heterogeneity in ADHD: DAT1 gene only affects probands without CD
Genetic heterogeneity in ADHD: DAT1 gene only affects probands without CD
Previous studies have found heterogeneous association between DAT1-3-UTR-VNTR and attention deficit hyperactivity disorder (ADHD). Various proportions of conduct disorder (CD) comorbidity in their ADHD samples may partially explain the observational discrepancies. Evidence for this comes from family and twin studies which found ADHD probands with CD (ADHD + CD) are genetically different from those without CD (ADHD - CD). Genotypes of 20 DAT1 markers were analyzed in 576 trios, consisting of 141 ADHD + CD and 435 ADHD - CD. In addition to the classical TDT test, a specific genetic heterogeneity test was performed to identify variants that have different transmission patterns in the two phenotypic subgroups. After multiple-test correction, rs40184 and rs2652511 were significant in TDT tests. Further heterogeneity test found the two SNPs had a significant transmission pattern difference between ADHD + CD and ADHD - CD children, indicating that DAT1 has a significantly greater genetic influence on ADHD without CD. Although the result needs further replications, it does highlight the importance of selecting genetically homogeneous samples for molecular genetic analyses of ADHD. © 2007 Wiley-Liss, Inc.
comorbidity, stratification, association
1552-4841
Zhou, K.
b7f35885-4647-46b1-acf8-c3bae7f50755
Chen, W.
99d5f0b4-a927-4e63-be3c-25fbbe9933bc
Buitelaar, J.
fa22aba5-1307-4627-9ae8-e564013a5af8
Banaschewski, T.
ca2651e5-143a-4171-b6d0-3e3853b684d8
Oades, R.D.
89c5ac77-d90a-4d61-8cd0-826e4c90441c
Franke, B.
d3276e6a-292a-489d-b589-de3af1b0162d
Sonuga-Barke, E.
bc80bf95-6cf9-4c76-a09d-eaaf0b717635
Ebstein, R.
451c2126-5196-41ff-81f9-490a200398e9
Eisenberg, J.
d91585a2-2d07-45b3-85e1-53b1ef09c0ea
Gill, M.
ae2696a2-c4b5-4a68-8f42-f26dbed5e251
Manor, I.
4e8bcd80-e32d-420c-9110-de08cff4aee3
Miranda, A.
8aa5d3d9-71b4-4498-b369-9fba532f5d4e
Mulas, F.
44612276-b250-4f01-97b3-46e115f49a25
Roeyers, H.
c97b7f56-f514-44cb-b7e2-545c68583d6e
Rothenberger, A.
f946fbda-7ceb-46b0-b48d-23cdaa4016aa
Sergeant, J.
76cfd9c5-bab9-4119-b5c2-af1749e22c71
Steinhausen, H.C.
dfa222f6-e520-4916-b628-d74ddda5c80f
Lasky-Su, J.
171c2348-a33d-4a69-84a4-9760ddbcce54
Taylor, E.
4528abc7-ae2b-4268-a646-68f9c2cae4d3
Keeley, J.B.
a5bc1a02-2812-4b9f-9f79-88260f5248f6
Xu, X.
6da974fd-c59c-4388-8eaf-73017928017a
Neale, B.
e8948089-07bd-407a-8ede-8051f536c8d1
Fruhling, R.
bfe8522c-b252-4771-8036-744e93357c67
Thompson, M.
9678cbee-9f4e-4eba-97d7-a8f573ff4901
Asherson, P.
4ecfa0c9-ea9c-47b9-aae8-429822c6c7ee
Faraone, S.V.
023439f0-0461-4037-9b79-27e0c25a9488
Zhou, K.
b7f35885-4647-46b1-acf8-c3bae7f50755
Chen, W.
99d5f0b4-a927-4e63-be3c-25fbbe9933bc
Buitelaar, J.
fa22aba5-1307-4627-9ae8-e564013a5af8
Banaschewski, T.
ca2651e5-143a-4171-b6d0-3e3853b684d8
Oades, R.D.
89c5ac77-d90a-4d61-8cd0-826e4c90441c
Franke, B.
d3276e6a-292a-489d-b589-de3af1b0162d
Sonuga-Barke, E.
bc80bf95-6cf9-4c76-a09d-eaaf0b717635
Ebstein, R.
451c2126-5196-41ff-81f9-490a200398e9
Eisenberg, J.
d91585a2-2d07-45b3-85e1-53b1ef09c0ea
Gill, M.
ae2696a2-c4b5-4a68-8f42-f26dbed5e251
Manor, I.
4e8bcd80-e32d-420c-9110-de08cff4aee3
Miranda, A.
8aa5d3d9-71b4-4498-b369-9fba532f5d4e
Mulas, F.
44612276-b250-4f01-97b3-46e115f49a25
Roeyers, H.
c97b7f56-f514-44cb-b7e2-545c68583d6e
Rothenberger, A.
f946fbda-7ceb-46b0-b48d-23cdaa4016aa
Sergeant, J.
76cfd9c5-bab9-4119-b5c2-af1749e22c71
Steinhausen, H.C.
dfa222f6-e520-4916-b628-d74ddda5c80f
Lasky-Su, J.
171c2348-a33d-4a69-84a4-9760ddbcce54
Taylor, E.
4528abc7-ae2b-4268-a646-68f9c2cae4d3
Keeley, J.B.
a5bc1a02-2812-4b9f-9f79-88260f5248f6
Xu, X.
6da974fd-c59c-4388-8eaf-73017928017a
Neale, B.
e8948089-07bd-407a-8ede-8051f536c8d1
Fruhling, R.
bfe8522c-b252-4771-8036-744e93357c67
Thompson, M.
9678cbee-9f4e-4eba-97d7-a8f573ff4901
Asherson, P.
4ecfa0c9-ea9c-47b9-aae8-429822c6c7ee
Faraone, S.V.
023439f0-0461-4037-9b79-27e0c25a9488

Zhou, K., Chen, W., Buitelaar, J., Banaschewski, T., Oades, R.D., Franke, B., Sonuga-Barke, E., Ebstein, R., Eisenberg, J., Gill, M., Manor, I., Miranda, A., Mulas, F., Roeyers, H., Rothenberger, A., Sergeant, J., Steinhausen, H.C., Lasky-Su, J., Taylor, E., Keeley, J.B., Xu, X., Neale, B., Fruhling, R., Thompson, M., Asherson, P. and Faraone, S.V. (2008) Genetic heterogeneity in ADHD: DAT1 gene only affects probands without CD. American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics. (doi:10.1002/ajmg.b.30644).

Record type: Article

Abstract

Previous studies have found heterogeneous association between DAT1-3-UTR-VNTR and attention deficit hyperactivity disorder (ADHD). Various proportions of conduct disorder (CD) comorbidity in their ADHD samples may partially explain the observational discrepancies. Evidence for this comes from family and twin studies which found ADHD probands with CD (ADHD + CD) are genetically different from those without CD (ADHD - CD). Genotypes of 20 DAT1 markers were analyzed in 576 trios, consisting of 141 ADHD + CD and 435 ADHD - CD. In addition to the classical TDT test, a specific genetic heterogeneity test was performed to identify variants that have different transmission patterns in the two phenotypic subgroups. After multiple-test correction, rs40184 and rs2652511 were significant in TDT tests. Further heterogeneity test found the two SNPs had a significant transmission pattern difference between ADHD + CD and ADHD - CD children, indicating that DAT1 has a significantly greater genetic influence on ADHD without CD. Although the result needs further replications, it does highlight the importance of selecting genetically homogeneous samples for molecular genetic analyses of ADHD. © 2007 Wiley-Liss, Inc.

This record has no associated files available for download.

More information

Published date: 18 December 2008
Keywords: comorbidity, stratification, association

Identifiers

Local EPrints ID: 54873
URI: http://eprints.soton.ac.uk/id/eprint/54873
ISSN: 1552-4841
PURE UUID: 741e106e-af20-4a8e-bf4e-91635348dcd5

Catalogue record

Date deposited: 04 Aug 2008
Last modified: 15 Mar 2024 10:51

Export record

Altmetrics

Contributors

Author: K. Zhou
Author: W. Chen
Author: J. Buitelaar
Author: T. Banaschewski
Author: R.D. Oades
Author: B. Franke
Author: E. Sonuga-Barke
Author: R. Ebstein
Author: J. Eisenberg
Author: M. Gill
Author: I. Manor
Author: A. Miranda
Author: F. Mulas
Author: H. Roeyers
Author: A. Rothenberger
Author: J. Sergeant
Author: H.C. Steinhausen
Author: J. Lasky-Su
Author: E. Taylor
Author: J.B. Keeley
Author: X. Xu
Author: B. Neale
Author: R. Fruhling
Author: M. Thompson
Author: P. Asherson
Author: S.V. Faraone

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×