Transgenic tilapia and the tilapia genome

Maclean, N., Rahman, M.A., Sohm, F., Hwang, G., Lyengar, A., Ayad, H., Smith, A. and Farahmand, H. (2002) Transgenic tilapia and the tilapia genome. Gene, 295, (2), 265-277. (doi:10.1016/S0378-1119(02)00735-7).


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The tilapia fish (Oreochromis niloticus) has an important place in the aquaculture of the developing world. It is also a very useful laboratory animal, and readily lends itself to the transgenic technology. Through the use of reporter genes, a range of potential gene promoters have been tested in tilapia, both through transient and stable expression of the reporter construct. Using the transgenic technology, growth enhanced lines of tilapia have been produced. These fish have no abnormalities and offer a considerable growth advantage for future exploitation. It is however crucial that transgenic fish, to be exploited in aquaculture, be sterile, and various methods of achieving sterility are considered. These include triploidy, gene knock out of crucial hormone encoding genes via homologous recombination, and knock down of the function of the same genes via ribozyme or antisense technologies.

Item Type: Article
ISSNs: 0378-1119 (print)
Related URLs:
Keywords: transgenic fish, reporter gene, antisense, ribozyme, biofactory
Subjects: Q Science > QH Natural history > QH301 Biology
Divisions: University Structure - Pre August 2011 > School of Biological Sciences
ePrint ID: 55813
Date Deposited: 06 Aug 2008
Last Modified: 06 Aug 2015 02:44

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