Inosine substitutions demonstrate that intramolecular DNA quadruplexes adopt different conformations in the presence of sodium and potassium


Risitano, A. and Fox, K.R. (2005) Inosine substitutions demonstrate that intramolecular DNA quadruplexes adopt different conformations in the presence of sodium and potassium. Bioorganic & Medicinal Chemistry Letters, 15, (8), 2047-2050. (doi:10.1016/j.bmcl.2005.02.050).

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Description/Abstract

We have examined the stability of fluorescently-labelled oligonucleotides that are based on the human telomeric repeat [(GGGTTA)3GGG], in which one of the guanines in turn is substituted with inosine. We show that the relative stability of the substitutions is different in the presence of sodium and potassium. The data for potassium suggest a parallel arrangement of the strands, while the sodium form is mixed parallel and antiparallel.

Graphical abstract
The relative stability of intramolecular quadruplexes containing inosine substitutions is different in sodium and potassium.

Item Type: Article
ISSNs: 0960-894X (print)
Related URLs:
Keywords: G-quartet, quadruplex, fluorescence, molecular beacon, DNA melting, inosine
Subjects: Q Science > Q Science (General)
R Medicine > R Medicine (General)
Divisions: University Structure - Pre August 2011 > School of Biological Sciences
ePrint ID: 55887
Date Deposited: 06 Aug 2008
Last Modified: 27 Mar 2014 18:38
URI: http://eprints.soton.ac.uk/id/eprint/55887

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