Inhibition of GABA uptake potentiates the effects of exogenous GABA on locust skeletal muscle


Shepherd, D. and Tyrer, N.M. (1985) Inhibition of GABA uptake potentiates the effects of exogenous GABA on locust skeletal muscle. Comparative Biochemistry and Physiology Part C: Comparative Pharmacology, 82, (2), 315-321. (doi:10.1016/0742-8413(85)90169-0).

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Description/Abstract

1. Insect skeletal muscle is relatively insensitive to applied GABA, responses are elicited only when relatively high concentrations of GABA are used (>10−6M).

2. Pretreatment of the muscle with the GABA uptake inhibitors nipecotic acid, β-aminobutyric acid or β-alanine increases the sensitivity of the muscle to GABA by as much as 1000-fold.

3. The evidence suggests the existence of a GABA uptake mechanism in the insect neuromuscular system which could reside in glial cells.

Item Type: Article
ISSNs: 0742-8413 (print)
Related URLs:
Subjects: Q Science > Q Science (General)
Q Science > QR Microbiology
Divisions: University Structure - Pre August 2011 > School of Biological Sciences
ePrint ID: 55893
Date Deposited: 22 Aug 2008
Last Modified: 27 Mar 2014 18:38
URI: http://eprints.soton.ac.uk/id/eprint/55893

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