Glial dependent survival of neurons in Drosophila
Glial dependent survival of neurons in Drosophila
According to the classical model of insect neurogenesis, neuron fate and survival is determined largely by cell autonomous mechanisms with no requirement for cell-cell interactions to control the total number of neurons. In a recent paper by Booth et al.,[(1)] however, the central tenet of this model has been called into question. Using a combination of mutations and targeted glial ablation, this paper shows that, contrary to common thinking, neuron survival in the embryonic nervous system of Drosophila is dependent upon normal glial function. This surprising result suggests that insect neurogenesis may have more in common with vertebrate neurogenesis than previously thought.
407-409
Shepherd, David
11aa6858-d19c-4450-82ff-11dff9dcd9c4
May 2000
Shepherd, David
11aa6858-d19c-4450-82ff-11dff9dcd9c4
Shepherd, David
(2000)
Glial dependent survival of neurons in Drosophila.
BioEssays, 22 (5), .
Abstract
According to the classical model of insect neurogenesis, neuron fate and survival is determined largely by cell autonomous mechanisms with no requirement for cell-cell interactions to control the total number of neurons. In a recent paper by Booth et al.,[(1)] however, the central tenet of this model has been called into question. Using a combination of mutations and targeted glial ablation, this paper shows that, contrary to common thinking, neuron survival in the embryonic nervous system of Drosophila is dependent upon normal glial function. This surprising result suggests that insect neurogenesis may have more in common with vertebrate neurogenesis than previously thought.
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Published date: May 2000
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Local EPrints ID: 55896
URI: http://eprints.soton.ac.uk/id/eprint/55896
ISSN: 0265-9247
PURE UUID: 841961a7-a2f0-4a9f-b994-4aa66140c149
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Date deposited: 21 Aug 2008
Last modified: 08 Jan 2022 16:02
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