Nerve growth factor induces the expression of the LIM homeodomain transcription factor Isl-1 with the kinetics of an immediate early gene in adult rat dorsal root ganglion
Jameson, H.L. and Lillycrop, K.A. (2001) Nerve growth factor induces the expression of the LIM homeodomain transcription factor Isl-1 with the kinetics of an immediate early gene in adult rat dorsal root ganglion. Neuroscience Letters, 309, (2), 130-134. (doi:10.1016/S0304-3940(01)02040-7).
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Description/Abstract
LIM-homeodomain genes encode a major class of transcription factors which play a critical role in regulating tissue specific gene expression. In this report, we have shown that three members of the LIM-homeodomain gene family - Isl-1, Rlim and Lim-3 are expressed in adult rat sensory neurons. Furthermore, we show that the addition of nerve growth factor (NGF) to cultures of primary dorsal root ganglion neurons leads to the induction of Isl-1, Rlim and Lim-3 mRNA expression. The increase in Isl-1 mRNA levels upon NGF addition was rapid and occurred even in the presence of cycloheximide. These findings place Isl-1 as a novel member of the immediate early class of genes. In contrast, Rlim and Lim-3mRNA induction by NGF required protein synthesis. The role of LIM-homeodomain genes in mediating responses to NGF in adult sensory neurons is discussed.
| Item Type: | Article |
|---|---|
| ISSNs: | 0304-3940 (print) |
| Related URLs: | |
| Keywords: | sensory neuron, dorsal root ganglion, LIM-homeodomain genes, nerve growth factor, immediate early genes, growth factors |
| Subjects: | Q Science > QH Natural history > QH301 Biology |
| Divisions: | University Structure - Pre August 2011 > School of Biological Sciences |
| Item ID: | 55901 |
| Date Deposited: | 06 Aug 2008 |
| Last Modified: | 12 May 2013 01:08 |
| Contributors: | Jameson, H.L. (Author) Lillycrop, K.A. (Author) |
| Date: | 24 August 2001 |
| Status: | Published |
| URI: | http://eprints.soton.ac.uk/id/eprint/55901 |
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