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Burrowing into prion disease: motivation, emotion, feeding, drinking

Burrowing into prion disease: motivation, emotion, feeding, drinking
Burrowing into prion disease: motivation, emotion, feeding, drinking
Mice received intra-hippocampal injections of scrapie-infected brain homogenate. Open field activity increased from around week 12 post-injection. Concomitantly the tendency to displace food from a tube inside the home cage decreased. The food was generally dug out with the feet, rather than carried by mouth, so its displacement was called burrowing. Food restriction was unnecessary for this burrowing to occur. Only later, around 18 weeks, did more general motor impairments develop. As burrowing in scrapie-infected mice decreased when open field activity increased, and preceded later motor impairments, it was not due to motor dysfunction. Burrowing is a simple, sensitive, objective, ethological measure, sensitive to preclinical prion disease. Other potential applications are in transgenic and knockout mice, models of ageing and Alzheimer's disease, and pharmacology, particularly neuroleptics.
2053-2057
Deacon, Robert M.J.
5e6a7058-2bbf-45f3-8c55-09a7f4a1dc9f
Raley, Josephine M.
851b2a53-8c88-4b55-8c5a-8f8773ea763e
Perry, V. Hugh
8f29d36a-8e1f-4082-8700-09483bbaeae4
Rawlins, J. Nicholas P.
99be6756-f34d-4880-8e7b-6f7ba2f6d92e
Deacon, Robert M.J.
5e6a7058-2bbf-45f3-8c55-09a7f4a1dc9f
Raley, Josephine M.
851b2a53-8c88-4b55-8c5a-8f8773ea763e
Perry, V. Hugh
8f29d36a-8e1f-4082-8700-09483bbaeae4
Rawlins, J. Nicholas P.
99be6756-f34d-4880-8e7b-6f7ba2f6d92e

Deacon, Robert M.J., Raley, Josephine M., Perry, V. Hugh and Rawlins, J. Nicholas P. (2001) Burrowing into prion disease: motivation, emotion, feeding, drinking. NeuroReport, 12 (9), 2053-2057.

Record type: Article

Abstract

Mice received intra-hippocampal injections of scrapie-infected brain homogenate. Open field activity increased from around week 12 post-injection. Concomitantly the tendency to displace food from a tube inside the home cage decreased. The food was generally dug out with the feet, rather than carried by mouth, so its displacement was called burrowing. Food restriction was unnecessary for this burrowing to occur. Only later, around 18 weeks, did more general motor impairments develop. As burrowing in scrapie-infected mice decreased when open field activity increased, and preceded later motor impairments, it was not due to motor dysfunction. Burrowing is a simple, sensitive, objective, ethological measure, sensitive to preclinical prion disease. Other potential applications are in transgenic and knockout mice, models of ageing and Alzheimer's disease, and pharmacology, particularly neuroleptics.

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Published date: 3 July 2001

Identifiers

Local EPrints ID: 55903
URI: http://eprints.soton.ac.uk/id/eprint/55903
PURE UUID: d9fbc431-3488-4e07-8935-8cb3084e77ae

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Date deposited: 08 Aug 2008
Last modified: 11 Dec 2021 17:46

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Contributors

Author: Robert M.J. Deacon
Author: Josephine M. Raley
Author: V. Hugh Perry
Author: J. Nicholas P. Rawlins

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