Cleavage of translation initiation factor 4AI (eIF4AI) but not eIF4AII by foot-and-mouth disease virus 3C protease: identification of the eIF4AI cleavage site
Lin, Wei, Ross-Smith, Natalie, Proud, Christopher G., Belsham, Graham J. and Avila, Jesus (ed.) (2001) Cleavage of translation initiation factor 4AI (eIF4AI) but not eIF4AII by foot-and-mouth disease virus 3C protease: identification of the eIF4AI cleavage site. FEBS Letters, 507, (1), 1-5.
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Description/Abstract
The translation initiation factor eIF4A is cleaved within mammalian cells infected by foot-and-mouth disease virus (FMDV). The FMDV 3C protease cleaves eIF4AI (between residues E143 and V144), but not the closely related eIF4AII. Modification of eIF4AI, to produce a sequence identical to eIF4AII around the cleavage site, blocked proteolysis. Alignment of mammalian eIF4AI onto the three-dimensional structure of yeast eIF4A located the scissile bond within an exposed, flexible portion of the molecule. The N- and C-terminal cleavage products of eIF4AI generated by FMDV 3C dissociate. Cleavage of eIF4AI by FMDV 3C is thus expected to inactivate it.
| Item Type: | Article |
|---|---|
| ISSNs: | 0014-5793 (print) |
| Related URLs: | |
| Keywords: | picornavirus, translation initiation factor eIF4A, protein synthesis, 3C protease, foot-and-mouth disease virus |
| Subjects: | Q Science > Q Science (General) R Medicine > R Medicine (General) |
| Divisions: | University Structure - Pre August 2011 > School of Biological Sciences |
| Item ID: | 55964 |
| Date Deposited: | 07 Aug 2008 |
| Last Modified: | 02 Mar 2012 13:10 |
| Contributors: | Lin, Wei (Author) Ross-Smith, Natalie (Author) Proud, Christopher G. (Author) Belsham, Graham J. (Author) Avila, Jesus (ed.) (Author) |
| Date: | 19 October 2001 |
| Status: | Published |
| URI: | http://eprints.soton.ac.uk/id/eprint/55964 |
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