P-1B-ATPases - an ancient family of transition metal pumps with diverse functions in plants
P-1B-ATPases - an ancient family of transition metal pumps with diverse functions in plants
P1B-ATPases form a distinct evolutionary sub-family of P-type ATPases, transporting transition metals such as Cu, Zn, Cd, Pb and Co across membranes in a wide range of organisms, including plants. Structurally they are distinct from other P-types, possessing eight transmembrane helices, a CPx/SPC motif in transmembrane domain six, and putative transition metal-binding domains at the N- and/or C-termini. Arabidopsis has eight P1B-ATPases (AtHMA1–AtHMA8), which differ in their structure, function and regulation. They perform a variety of important physiological tasks relating to transition metal transport and homeostasis. The crucial roles of plant P1B-ATPases in micronutrient nutrition, delivery of essential metals to target proteins, and toxic metal detoxification are discussed.
491-502
Williams, Lorraine E.
79ee1856-3732-492b-8ac5-239749c85d9e
Mills, Rebecca F.
dec4afc8-be3b-4517-9038-c3c3e8b71b35
October 2005
Williams, Lorraine E.
79ee1856-3732-492b-8ac5-239749c85d9e
Mills, Rebecca F.
dec4afc8-be3b-4517-9038-c3c3e8b71b35
Williams, Lorraine E. and Mills, Rebecca F.
(2005)
P-1B-ATPases - an ancient family of transition metal pumps with diverse functions in plants.
Trends in Plant Science, 10 (10), .
(doi:10.1016/j.tplants.2005.08.008).
Abstract
P1B-ATPases form a distinct evolutionary sub-family of P-type ATPases, transporting transition metals such as Cu, Zn, Cd, Pb and Co across membranes in a wide range of organisms, including plants. Structurally they are distinct from other P-types, possessing eight transmembrane helices, a CPx/SPC motif in transmembrane domain six, and putative transition metal-binding domains at the N- and/or C-termini. Arabidopsis has eight P1B-ATPases (AtHMA1–AtHMA8), which differ in their structure, function and regulation. They perform a variety of important physiological tasks relating to transition metal transport and homeostasis. The crucial roles of plant P1B-ATPases in micronutrient nutrition, delivery of essential metals to target proteins, and toxic metal detoxification are discussed.
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Published date: October 2005
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Local EPrints ID: 55970
URI: http://eprints.soton.ac.uk/id/eprint/55970
ISSN: 1360-1385
PURE UUID: 781bca34-8455-42ba-ac37-a773c174799c
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Date deposited: 08 Aug 2008
Last modified: 15 Mar 2024 10:58
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Author:
Rebecca F. Mills
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