Junctional complexes in the early mammalian embryo


Fleming, T.P., Ghassemifar, M.R. and Sheth, B. (2000) Junctional complexes in the early mammalian embryo. Seminars in Reproductive Medicine, 18, (2), 185-193. (doi:10.1055/s-2000-12557).

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Original Publication URL: http://dx.doi.org/10.1055/s-2000-12557

Description/Abstract

Preimplantation embryos generate intercellular junctions during differentiation of the trophectoderm epithelium and the formation of the blastocyst. These membrane complexes comprise gap junctions, adherens junctions, tight junctions, and desmosomes, each performing fundamental roles in cellular communication, adhesion, and differentiation. The mouse embryo has been used as a model for the biogenesis of cell junctions. Their construction is achieved by temporally regulated gene expression programs. Mechanisms of junction membrane assembly include the timing of transcription, translation, and posttranslational modifications of specific junctional proteins. Human embryos exhibit similar expression programs, and defects in these programs may contribute to reduced embryo viability.

Item Type: Article
ISSNs: 1526-8004 (print)
Related URLs:
Keywords: junctions, blastocyst
Subjects: R Medicine > RG Gynecology and obstetrics
Q Science > QR Microbiology
Q Science > QM Human anatomy
Divisions: University Structure - Pre August 2011 > School of Biological Sciences
ePrint ID: 56005
Date Deposited: 21 Aug 2008
Last Modified: 27 Mar 2014 18:38
URI: http://eprints.soton.ac.uk/id/eprint/56005

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