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Junctional complexes in the early mammalian embryo

Junctional complexes in the early mammalian embryo
Junctional complexes in the early mammalian embryo
Preimplantation embryos generate intercellular junctions during differentiation of the trophectoderm epithelium and the formation of the blastocyst. These membrane complexes comprise gap junctions, adherens junctions, tight junctions, and desmosomes, each performing fundamental roles in cellular communication, adhesion, and differentiation. The mouse embryo has been used as a model for the biogenesis of cell junctions. Their construction is achieved by temporally regulated gene expression programs. Mechanisms of junction membrane assembly include the timing of transcription, translation, and posttranslational modifications of specific junctional proteins. Human embryos exhibit similar expression programs, and defects in these programs may contribute to reduced embryo viability.
junctions, blastocyst
185-193
Fleming, T.P.
2abf761a-e5a1-4fa7-a2c8-12e32d5d4c03
Ghassemifar, M.R.
219dba14-d37d-4062-b687-bcdcc6889045
Sheth, B.
2ca6ed58-a992-47b7-b3a5-3c5df82aada7
Fleming, T.P.
2abf761a-e5a1-4fa7-a2c8-12e32d5d4c03
Ghassemifar, M.R.
219dba14-d37d-4062-b687-bcdcc6889045
Sheth, B.
2ca6ed58-a992-47b7-b3a5-3c5df82aada7

Fleming, T.P., Ghassemifar, M.R. and Sheth, B. (2000) Junctional complexes in the early mammalian embryo. Seminars in Reproductive Medicine, 18 (2), 185-193. (doi:10.1055/s-2000-12557).

Record type: Article

Abstract

Preimplantation embryos generate intercellular junctions during differentiation of the trophectoderm epithelium and the formation of the blastocyst. These membrane complexes comprise gap junctions, adherens junctions, tight junctions, and desmosomes, each performing fundamental roles in cellular communication, adhesion, and differentiation. The mouse embryo has been used as a model for the biogenesis of cell junctions. Their construction is achieved by temporally regulated gene expression programs. Mechanisms of junction membrane assembly include the timing of transcription, translation, and posttranslational modifications of specific junctional proteins. Human embryos exhibit similar expression programs, and defects in these programs may contribute to reduced embryo viability.

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More information

Published date: 1 January 2000
Keywords: junctions, blastocyst

Identifiers

Local EPrints ID: 56005
URI: http://eprints.soton.ac.uk/id/eprint/56005
PURE UUID: eae382ae-dd2f-4677-89bf-8c3698584158

Catalogue record

Date deposited: 21 Aug 2008
Last modified: 15 Mar 2024 10:59

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Contributors

Author: T.P. Fleming
Author: M.R. Ghassemifar
Author: B. Sheth

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