How lipids and proteins interact in a membrane: a molecular approach
Lee, A.G. (2005) How lipids and proteins interact in a membrane: a molecular approach. Molecular BioSystems, 1, 203-212. (doi:10.1039/b504527d).
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Description/Abstract
Membrane proteins in a biological membrane are surrounded by a shell or annulus of ‘solvent’ lipid molecules. These lipid molecules in general interact rather non-specifically with the protein molecules, although a few ‘hot-spots’ may be present on the protein where anionic lipids bind with high affinity. Because of the low structural specificity of most of the annular sites, the composition of the lipid annulus will be rather similar to the bulk lipid composition of the membrane. The structures of the solvent lipid molecules are important in determining the conformational state of a membrane protein, and hence its activity, through charge and hydrogen bonding interactions between the lipid headgroups and residues in the protein, and through hydrophobic matching between the protein and the surrounding lipid bilayer. Evidence is also accumulating for the presence of ‘co-factor’ lipid molecules binding with high specificity to membrane proteins, often between transmembrane a-helices, and often being essential for activity.
| Item Type: | Article |
|---|---|
| ISSNs: | 1742-206X (print) |
| Related URLs: | |
| Subjects: | Q Science > QH Natural history > QH301 Biology |
| Divisions: | University Structure - Pre August 2011 > School of Biological Sciences |
| Item ID: | 56201 |
| Date Deposited: | 06 Aug 2008 |
| Last Modified: | 01 Jun 2011 12:09 |
| Contributors: | Lee, A.G. (Author) |
| Date: | 1 September 2005 |
| Status: | Published |
| URI: | http://eprints.soton.ac.uk/id/eprint/56201 |
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