The University of Southampton
University of Southampton Institutional Repository

Signalling to translation: how signal transduction pathways control the protein synthetic machinery

Signalling to translation: how signal transduction pathways control the protein synthetic machinery
Signalling to translation: how signal transduction pathways control the protein synthetic machinery
Recent advances in our understanding of both the regulation of components of the translational machinery and the upstream signalling pathways that modulate them have provided important new insights into the mechanisms by which hormones, growth factors, nutrients and cellular energy status control protein synthesis in mammalian cells. The importance of proper control of mRNA translation is strikingly illustrated by the fact that defects in this process or its control are implicated in a number of disease states, such as cancer, tissue hypertrophy and neurodegeneration. Signalling pathways such as those involving mTOR (mammalian target of rapamycin) and mitogen-activated protein kinases modulate the phosphorylation of translation factors, the activities of the protein kinases that act upon them and the association of RNA-binding proteins with specific mRNAs. These effects contribute both to the overall control of protein synthesis (which is linked to cell growth) and to the modulation of the translation or stability of specific mRNAs. However, important questions remain about both the contributions of individual regulatory events to the control of general protein synthesis and the mechanisms by which the translation of specific mRNAs is controlled.
mammalian target of rapamycin (mTOR), mRNA, mRNA translation, ribosome, signal transduction, translation factor
1470-8728
217-234
Proud, C.G.
c2cc50f9-4565-4d59-9dfc-aa70b9268a6e
Proud, C.G.
c2cc50f9-4565-4d59-9dfc-aa70b9268a6e

Proud, C.G. (2007) Signalling to translation: how signal transduction pathways control the protein synthetic machinery. Biochemical Journal, 403 (2), 217-234. (doi:10.1042/BJ20070024).

Record type: Article

Abstract

Recent advances in our understanding of both the regulation of components of the translational machinery and the upstream signalling pathways that modulate them have provided important new insights into the mechanisms by which hormones, growth factors, nutrients and cellular energy status control protein synthesis in mammalian cells. The importance of proper control of mRNA translation is strikingly illustrated by the fact that defects in this process or its control are implicated in a number of disease states, such as cancer, tissue hypertrophy and neurodegeneration. Signalling pathways such as those involving mTOR (mammalian target of rapamycin) and mitogen-activated protein kinases modulate the phosphorylation of translation factors, the activities of the protein kinases that act upon them and the association of RNA-binding proteins with specific mRNAs. These effects contribute both to the overall control of protein synthesis (which is linked to cell growth) and to the modulation of the translation or stability of specific mRNAs. However, important questions remain about both the contributions of individual regulatory events to the control of general protein synthesis and the mechanisms by which the translation of specific mRNAs is controlled.

This record has no associated files available for download.

More information

Submitted date: 3 January 2007
Published date: 1 April 2007
Keywords: mammalian target of rapamycin (mTOR), mRNA, mRNA translation, ribosome, signal transduction, translation factor

Identifiers

Local EPrints ID: 56275
URI: http://eprints.soton.ac.uk/id/eprint/56275
ISSN: 1470-8728
PURE UUID: 111eea0c-6777-4766-9c3b-8bf1d0516739

Catalogue record

Date deposited: 06 Aug 2008
Last modified: 15 Mar 2024 11:00

Export record

Altmetrics

Contributors

Author: C.G. Proud

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×