Creating porous tubes by centrifugal forces for soft tissue application

Dalton, Paul.D. and Shoichet, Molly.S. (2001) Creating porous tubes by centrifugal forces for soft tissue application. Biomaterials, 22, (19), 2661-2669. (doi:10.1016/S0142-9612(01)00008-4).


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Chemically crosslinked poly(2-hydroxyethyl methacrylate) (PHEMA) tubes were synthesized by applying centrifugal forces to propagating polymer chains in solution. Initiated monomer solutions, with a composition typical for PHEMA sponges, were placed into a cylindrical mold that was rotated about its long axis. As polymerization proceeded, phase separated PHEMA formed a sediment at the periphery under centrifugal action. The solvent remained in the center of the mold while the PHEMA phase gelled, resulting in a tube. By controlling the rotational speed and the formulation chemistry (i.e., monomer, initiator and crosslinking agent concentrations), the tube dimensions and wall morphology were manipulated. Tube manufacture was limited by a critical casting concentration [M]c, above which only rods formed. All tubes had an outer diameter of 2.4 mm, reflecting the internal diameter of the mold and a wall thickness of approximately 40–400 ?m. Wall morphologies varied from interconnecting polymer and water phases to a closed cell, gel-like, structure. Concentric tubes were successfully prepared by using formulations that enhanced phase separation over gelation/network formation. This was achieved by using formulations with lower concentrations of monomer and crosslinking agent and higher concentrations of initiator. This technique offers a new approach to the synthesis of polymeric tubes for use in soft tissue applications, such as nerve guidance channels.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1016/S0142-9612(01)00008-4
ISSNs: 0142-9612 (print)
Related URLs:
Keywords: poly(2-hydroxyethyl methacrylate), high gravity, hydrogel, phase separation, hollow fiber membrane, guidance channel
Subjects: Q Science > Q Science (General)
Divisions : University Structure - Pre August 2011 > School of Biological Sciences
ePrint ID: 56277
Accepted Date and Publication Date:
1 October 2001Published
Date Deposited: 07 Aug 2008
Last Modified: 31 Mar 2016 12:36

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