Pro-epileptic changes in synaptic function can be accompanied by pro-epileptic changes in neuronal excitability


Wheal, H.V., Bernard, C., Chad, J.E. and Cannon, R.C. (1998) Pro-epileptic changes in synaptic function can be accompanied by pro-epileptic changes in neuronal excitability. Trends in Neurosciences, 21, (4), 167-174. (doi:10.1016/S0166-2236(97)01182-X).

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Description/Abstract

Repetitive sensory input, stroboscopic lights or repeated sounds can induce epileptic seizures in susceptible individuals. In order to understand the process we have to consider multiple factors. The output of a set of neurones is determined by the amount of excitatory synaptic input, the degree of positive feedback and their inherent electrical excitability, which can be modified by synaptic inhibition. Recent research has shown that it is possible to separate these phenomena, and that they do not always behave in unison.

Item Type: Article
ISSNs: 0166-2236 (print)
Related URLs:
Keywords: epilepsy, Ca2+ channels, sodium channels, NMDA receptors, AMPA receptors, synapses, E/S, LTP, LTD
Subjects: R Medicine > R Medicine (General)
Q Science > QR Microbiology
Divisions: University Structure - Pre August 2011 > School of Biological Sciences
ePrint ID: 56308
Date Deposited: 22 Aug 2008
Last Modified: 27 Mar 2014 18:39
URI: http://eprints.soton.ac.uk/id/eprint/56308

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