The University of Southampton
University of Southampton Institutional Repository

Systemic infections and inflammation affect chronic neurodegeneration

Systemic infections and inflammation affect chronic neurodegeneration
Systemic infections and inflammation affect chronic neurodegeneration
It is well known that systemic infections cause flare-ups of disease in individuals with asthma and rheumatoid arthritis, and that relapses in multiple sclerosis can often be associated with upper respiratory-tract infections. Here we review evidence to support our hypothesis that in chronic neurodegenerative diseases such as Alzheimer's disease, with an ongoing innate immune response in the brain, systemic infections and inflammation can cause acute exacerbations of symptoms and drive the progression of neurodegeneration.
1474-1733
161-167
Perry, V.H.
8f29d36a-8e1f-4082-8700-09483bbaeae4
Cunningham, C.
6d675038-a4b1-46e2-9e4b-0a5ac27ea2b2
Holmes, C.
ada5abf3-8459-4cf7-be40-3f4e9391cc96
Perry, V.H.
8f29d36a-8e1f-4082-8700-09483bbaeae4
Cunningham, C.
6d675038-a4b1-46e2-9e4b-0a5ac27ea2b2
Holmes, C.
ada5abf3-8459-4cf7-be40-3f4e9391cc96

Perry, V.H., Cunningham, C. and Holmes, C. (2007) Systemic infections and inflammation affect chronic neurodegeneration. Nature Reviews Immunology, 7 (2), 161-167. (doi:10.1038/nri2015).

Record type: Article

Abstract

It is well known that systemic infections cause flare-ups of disease in individuals with asthma and rheumatoid arthritis, and that relapses in multiple sclerosis can often be associated with upper respiratory-tract infections. Here we review evidence to support our hypothesis that in chronic neurodegenerative diseases such as Alzheimer's disease, with an ongoing innate immune response in the brain, systemic infections and inflammation can cause acute exacerbations of symptoms and drive the progression of neurodegeneration.

This record has no associated files available for download.

More information

Published date: February 2007

Identifiers

Local EPrints ID: 56335
URI: http://eprints.soton.ac.uk/id/eprint/56335
ISSN: 1474-1733
PURE UUID: 927db74e-4044-4ae4-8815-d231b0003515
ORCID for C. Holmes: ORCID iD orcid.org/0000-0003-1999-6912

Catalogue record

Date deposited: 08 Aug 2008
Last modified: 16 Mar 2024 03:07

Export record

Altmetrics

Contributors

Author: V.H. Perry
Author: C. Cunningham
Author: C. Holmes ORCID iD

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×