Systemic infections and inflammation affect chronic neurodegeneration

Perry, V.H., Cunningham, C. and Holmes, C. (2007) Systemic infections and inflammation affect chronic neurodegeneration. Nature Reviews Immunology, 7, (2), 161-167. (doi:10.1038/nri2015).


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It is well known that systemic infections cause flare-ups of disease in individuals with asthma and rheumatoid arthritis, and that relapses in multiple sclerosis can often be associated with upper respiratory-tract infections. Here we review evidence to support our hypothesis that in chronic neurodegenerative diseases such as Alzheimer's disease, with an ongoing innate immune response in the brain, systemic infections and inflammation can cause acute exacerbations of symptoms and drive the progression of neurodegeneration.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1038/nri2015
ISSNs: 1474-1733 (print)
Related URLs:
Subjects: Q Science > Q Science (General)
R Medicine > R Medicine (General)
Divisions : University Structure - Pre August 2011 > School of Biological Sciences
ePrint ID: 56335
Accepted Date and Publication Date:
February 2007Published
Date Deposited: 08 Aug 2008
Last Modified: 31 Mar 2016 12:36

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