Systemic infections and inflammation affect chronic neurodegeneration
Perry, V.H., Cunningham, C. and Holmes, C. (2007) Systemic infections and inflammation affect chronic neurodegeneration. Nature Reviews Immunology, 7, (2), 161-167. (doi:10.1038/nri2015).
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Description/Abstract
It is well known that systemic infections cause flare-ups of disease in individuals with asthma and rheumatoid arthritis, and that relapses in multiple sclerosis can often be associated with upper respiratory-tract infections. Here we review evidence to support our hypothesis that in chronic neurodegenerative diseases such as Alzheimer's disease, with an ongoing innate immune response in the brain, systemic infections and inflammation can cause acute exacerbations of symptoms and drive the progression of neurodegeneration.
| Item Type: | Article |
|---|---|
| ISSNs: | 1474-1733 (print) |
| Related URLs: | |
| Subjects: | Q Science > Q Science (General) R Medicine > R Medicine (General) |
| Divisions: | University Structure - Pre August 2011 > School of Biological Sciences |
| Item ID: | 56335 |
| Date Deposited: | 08 Aug 2008 |
| Last Modified: | 01 Jun 2011 04:53 |
| Contributors: | Perry, V.H. (Author) Cunningham, C. (Author) Holmes, C. (Author) |
| Date: | February 2007 |
| Status: | Published |
| URI: | http://eprints.soton.ac.uk/id/eprint/56335 |
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