Lipid interactions with ion channels

Lee, A.G. (2007) Lipid interactions with ion channels. Future Lipidology, 1, (1), 103-113. (doi:10.2217/17460875.1.1.103).


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This review describes how ion channels interact with the lipid molecules that surround them in a biological membrane and how these interactions affect ion channel function. The composition of the ring, or annulus, of lipid molecules surrounding an ion channel in the membrane will be different to the bulk lipid composition of the membrane if the ion channel has different affinities for different species of phospholipids. Interactions with anionic lipid molecules, particularly with the phosphoinositides, are important for the function of many ion channels. The determination of high-resolution structures for a number of ion channels has provided a framework within which to understand lipid–ion channel interactions at the molecular level.

Item Type: Article
Digital Object Identifier (DOI): doi:10.2217/17460875.1.1.103
ISSNs: 1746-0875 (print)
Related URLs:
Subjects: Q Science > QD Chemistry
Q Science > QH Natural history > QH301 Biology
Divisions : University Structure - Pre August 2011 > School of Biological Sciences
ePrint ID: 56369
Accepted Date and Publication Date:
1 February 2007Published
Date Deposited: 06 Aug 2008
Last Modified: 31 Mar 2016 12:36

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