Ca2+ transport by the synaptosomal plasma membrane Ca2+-ATPase and the effect of thioridazine
Palacios, J., Sepulveda, M.R., Lee, A.G. and Mata, A.M. (2004) Ca2+ transport by the synaptosomal plasma membrane Ca2+-ATPase and the effect of thioridazine. Biochemistry - US, 43, (8), 2353-2358. (doi:10.1021/bi0359473).
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Description/Abstract
Thioridazine inhibits the activity of the synaptic plasma membrane Ca2+-ATPase from pig brain and slightly decreases the rate of Ca2+ accumulation by synaptic plasma membrane vesicles in the absence of phosphate. However, in the presence of phosphate, thioridazine increases the rate of Ca2+ accumulation into synaptic plasma membrane vesicles. Phosphate anions diffuse through the membrane and form calcium phosphate crystals, reducing the free Ca2+ concentration inside the vesicles and the rate of Ca2+ leak. The higher levels of Ca2+ accumulation obtained in the presence of thioridazine could be explained by a reduction of the rate of slippage on the plasma membrane ATPase.
| Item Type: | Article |
|---|---|
| ISSNs: | 0006-2960 (print) |
| Related URLs: | |
| Subjects: | Q Science > QD Chemistry Q Science > QH Natural history > QH301 Biology |
| Divisions: | University Structure - Pre August 2011 > School of Biological Sciences |
| Item ID: | 56437 |
| Date Deposited: | 07 Aug 2008 |
| Last Modified: | 12 May 2013 01:14 |
| Contributors: | Palacios, J. (Author) Sepulveda, M.R. (Author) Lee, A.G. (Author) Mata, A.M. (Author) |
| Date: | 1 March 2004 |
| Status: | Published |
| URI: | http://eprints.soton.ac.uk/id/eprint/56437 |
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