Ca2+ transport by the synaptosomal plasma membrane Ca2+-ATPase and the effect of thioridazine


Palacios, J., Sepulveda, M.R., Lee, A.G. and Mata, A.M. (2004) Ca2+ transport by the synaptosomal plasma membrane Ca2+-ATPase and the effect of thioridazine. Biochemistry - US, 43, (8), 2353-2358. (doi:10.1021/bi0359473).

Download

Full text not available from this repository.

Original Publication URL: http://dx.doi.org/10.1021/bi0359473

Description/Abstract

Thioridazine inhibits the activity of the synaptic plasma membrane Ca2+-ATPase from pig brain and slightly decreases the rate of Ca2+ accumulation by synaptic plasma membrane vesicles in the absence of phosphate. However, in the presence of phosphate, thioridazine increases the rate of Ca2+ accumulation into synaptic plasma membrane vesicles. Phosphate anions diffuse through the membrane and form calcium phosphate crystals, reducing the free Ca2+ concentration inside the vesicles and the rate of Ca2+ leak. The higher levels of Ca2+ accumulation obtained in the presence of thioridazine could be explained by a reduction of the rate of slippage on the plasma membrane ATPase.

Item Type: Article
ISSNs: 0006-2960 (print)
Related URLs:
Subjects: Q Science > QD Chemistry
Q Science > QH Natural history > QH301 Biology
Divisions: University Structure - Pre August 2011 > School of Biological Sciences
ePrint ID: 56437
Date Deposited: 07 Aug 2008
Last Modified: 27 Mar 2014 18:39
URI: http://eprints.soton.ac.uk/id/eprint/56437

Actions (login required)

View Item View Item