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What is immune privilege (not)?

What is immune privilege (not)?
What is immune privilege (not)?
The ‘immune privilege’ of the central nervous system (CNS) is indispensable for damage limitation during inflammation in a sensitive organ with poor regenerative capacity. It is a longstanding notion which, over time, has acquired several misconceptions and a lack of precision in its definition. In this article, we address these issues and re-define CNS immune privilege in the light of recent data. We show how it is far from absolute, and how it varies with age and brain region. Immune privilege in the CNS is often mis-attributed wholly to the blood–brain barrier. We discuss the pivotal role of the specialization of the afferent arm of adaptive immunity in the brain, which results in a lack of cell-mediated antigen drainage to the cervical lymph nodes although soluble drainage to these nodes is well described. It is now increasingly recognized how immune privilege is maintained actively as a result of the immunoregulatory characteristics of the CNS-resident cells and their microenvironment.
1471-4906
12-18
Galea, Ian
66209a2f-f7e6-4d63-afe4-e9299f156f0b
Bechmann, Ingo
4b42706d-4154-4bfe-b30b-e6830e1d63cd
Perry, V.Hugh
8f29d36a-8e1f-4082-8700-09483bbaeae4
Galea, Ian
66209a2f-f7e6-4d63-afe4-e9299f156f0b
Bechmann, Ingo
4b42706d-4154-4bfe-b30b-e6830e1d63cd
Perry, V.Hugh
8f29d36a-8e1f-4082-8700-09483bbaeae4

Galea, Ian, Bechmann, Ingo and Perry, V.Hugh (2007) What is immune privilege (not)? Trends in Immunology, 28 (1), 12-18. (doi:10.1016/j.it.2006.11.004).

Record type: Review

Abstract

The ‘immune privilege’ of the central nervous system (CNS) is indispensable for damage limitation during inflammation in a sensitive organ with poor regenerative capacity. It is a longstanding notion which, over time, has acquired several misconceptions and a lack of precision in its definition. In this article, we address these issues and re-define CNS immune privilege in the light of recent data. We show how it is far from absolute, and how it varies with age and brain region. Immune privilege in the CNS is often mis-attributed wholly to the blood–brain barrier. We discuss the pivotal role of the specialization of the afferent arm of adaptive immunity in the brain, which results in a lack of cell-mediated antigen drainage to the cervical lymph nodes although soluble drainage to these nodes is well described. It is now increasingly recognized how immune privilege is maintained actively as a result of the immunoregulatory characteristics of the CNS-resident cells and their microenvironment.

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More information

Published date: January 2007

Identifiers

Local EPrints ID: 56463
URI: http://eprints.soton.ac.uk/id/eprint/56463
ISSN: 1471-4906
PURE UUID: d7477a40-8d4f-4d89-abbf-fdb5d91eda62
ORCID for Ian Galea: ORCID iD orcid.org/0000-0002-1268-5102

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Date deposited: 08 Aug 2008
Last modified: 16 Mar 2024 03:33

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Contributors

Author: Ian Galea ORCID iD
Author: Ingo Bechmann
Author: V.Hugh Perry

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