Localisation and regulation of the eIF4E-binding protein 4E-BP3
Kleijn, M., Scheper, G.C., Wilson, M.L., Tee, A.R. and Proud, C.G. (2002) Localisation and regulation of the eIF4E-binding protein 4E-BP3. Federation of European Biochemical Societies (FEBS) Letters, 532, (3), 319-323.
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The cap-binding protein eIF4E-binding protein 3 (4E-BP3) was identified some years ago, but its properties have not been investigated in detail. In this report, we investigated the regulation and localisation of 4E-BP3. We show that 4E-BP3 is present in the nucleus as well as in the cytoplasm in primary T cells, HEK293 cells and HeLa cells. 4E-BP3 was associated with eIF4E in both cell compartments. Furthermore, 4E-BP3/eIF4E association in the cytoplasm was regulated by serum or interleukin-2 starvation in the different cell types. Rapamycin did not affect the association of eIF4E with 4E-BP3 in the cytoplasm or in the nucleus.
|Keywords:||eIF4E-binding protein 3, eIF4E-binding protein 1, primary T cell, regulation, nucleus|
|Subjects:||Q Science > QD Chemistry
Q Science > QH Natural history > QH301 Biology
|Divisions:||University Structure - Pre August 2011 > School of Biological Sciences
|Date Deposited:||07 Aug 2008|
|Last Modified:||12 Jul 2013 01:09|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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