Localisation and regulation of the eIF4E-binding protein 4E-BP3
Kleijn, M., Scheper, G.C., Wilson, M.L., Tee, A.R. and Proud, C.G. (2002) Localisation and regulation of the eIF4E-binding protein 4E-BP3. Federation of European Biochemical Societies (FEBS) Letters, 532, (3), 319-323.
Download
Full text not available from this repository.
Description/Abstract
The cap-binding protein eIF4E-binding protein 3 (4E-BP3) was identified some years ago, but its properties have not been investigated in detail. In this report, we investigated the regulation and localisation of 4E-BP3. We show that 4E-BP3 is present in the nucleus as well as in the cytoplasm in primary T cells, HEK293 cells and HeLa cells. 4E-BP3 was associated with eIF4E in both cell compartments. Furthermore, 4E-BP3/eIF4E association in the cytoplasm was regulated by serum or interleukin-2 starvation in the different cell types. Rapamycin did not affect the association of eIF4E with 4E-BP3 in the cytoplasm or in the nucleus.
| Item Type: | Article |
|---|---|
| ISSNs: | 0014-5793 (print) |
| Related URLs: | |
| Keywords: | eIF4E-binding protein 3, eIF4E-binding protein 1, primary T cell, regulation, nucleus |
| Subjects: | Q Science > QD Chemistry Q Science > QH Natural history > QH301 Biology |
| Divisions: | University Structure - Pre August 2011 > School of Biological Sciences |
| Item ID: | 56620 |
| Date Deposited: | 07 Aug 2008 |
| Last Modified: | 11 Jun 2013 01:48 |
| Contributors: | Kleijn, M. (Author) Scheper, G.C. (Author) Wilson, M.L. (Author) Tee, A.R. (Author) Proud, C.G. (Author) |
| Date: | 1 December 2002 |
| Status: | Published |
| URI: | http://eprints.soton.ac.uk/id/eprint/56620 |
Actions (login required)
 |
View Item |
