Localisation and regulation of the eIF4E-binding protein 4E-BP3


Kleijn, M., Scheper, G.C., Wilson, M.L., Tee, A.R. and Proud, C.G. (2002) Localisation and regulation of the eIF4E-binding protein 4E-BP3. Federation of European Biochemical Societies (FEBS) Letters, 532, (3), 319-323.

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Description/Abstract

The cap-binding protein eIF4E-binding protein 3 (4E-BP3) was identified some years ago, but its properties have not been investigated in detail. In this report, we investigated the regulation and localisation of 4E-BP3. We show that 4E-BP3 is present in the nucleus as well as in the cytoplasm in primary T cells, HEK293 cells and HeLa cells. 4E-BP3 was associated with eIF4E in both cell compartments. Furthermore, 4E-BP3/eIF4E association in the cytoplasm was regulated by serum or interleukin-2 starvation in the different cell types. Rapamycin did not affect the association of eIF4E with 4E-BP3 in the cytoplasm or in the nucleus.

Item Type: Article
ISSNs: 0014-5793 (print)
Related URLs:
Keywords: eIF4E-binding protein 3, eIF4E-binding protein 1, primary T cell, regulation, nucleus
Subjects: Q Science > QD Chemistry
Q Science > QH Natural history > QH301 Biology
Divisions: University Structure - Pre August 2011 > School of Biological Sciences
ePrint ID: 56620
Date Deposited: 07 Aug 2008
Last Modified: 27 Mar 2014 18:39
URI: http://eprints.soton.ac.uk/id/eprint/56620

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