Molecular characterization of the metabotropic glutamate receptor family in Caenorhabditis elegans
Dillon, J., Hopper, N.A., Holden-Dye, L. and Connor, V. (2006) Molecular characterization of the metabotropic glutamate receptor family in Caenorhabditis elegans. Biochemical Society Transactions, 34, (5), 942-948.
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mGluRs (metabotropic glutamate receptors) are G-protein-coupled receptors that play an important neuromodulatory role in the brain. Glutamatergic transmission itself plays a fundamental role in the simple nervous system of the model organism Caenorhabditis elegans, but little is known about the contribution made by mGluR signalling. The sequenced genome of C. elegans predicts three distinct genes, mgl-1, mgl-2 and mgl-3 (designated Y4C6A.2). We have used in silico and cDNA analyses to investigate the genes encoding mgls. Our results indicate that mgl genes constitute a gene family made up of three distinct subclasses of receptor. Our transcript analysis highlights potential for complex gene regulation with respect to both expression and splicing. Further, we identify that the predicted proteins encoded by mgls harbour structural motifs that are likely to regulate function. Taken together, this molecular characterization provides a platform to further investigate mGluR function in the model organism C. elegans.
|Keywords:||Caenorhabditis elegans, G-protein-coupled receptor; metabotropic glutamate receptor, molecular characterization, rapid amplification of cDNA ends (RACE), splice leader-1 (SL-1)|
|Subjects:||Q Science > Q Science (General)
R Medicine > R Medicine (General)
|Divisions:||University Structure - Pre August 2011 > School of Biological Sciences
|Date Deposited:||06 Aug 2008|
|Last Modified:||12 Jul 2013 01:10|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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