Translation matters: protein synthesis defects in inherited disease


Scheper, G.C., van der Knaap, M.S. and Proud, C.G. (2007) Translation matters: protein synthesis defects in inherited disease. Nature Reviews Genetics, 8, (9), 711-723. (doi:10.1038/nrg2142).

Download

Full text not available from this repository.

Original Publication URL: http://dx.doi.org/10.1038/nrg2142

Description/Abstract

The list of genetic diseases caused by mutations that affect mRNA translation is rapidly growing. Although protein synthesis is a fundamental process in all cells, the disease phenotypes show a surprising degree of heterogeneity. Studies of some of these diseases have provided intriguing new insights into the functions of proteins involved in the process of translation; for example, evidence suggests that several have other functions in addition to their roles in translation. Given the numerous proteins involved in mRNA translation, it is likely that further inherited diseases will turn out to be caused by mutations in genes that are involved in this complex process.

Item Type: Article
ISSNs: 1471-0056 (print)
Related URLs:
Subjects: Q Science > QH Natural history > QH426 Genetics
Q Science > QH Natural history > QH301 Biology
Divisions: University Structure - Pre August 2011 > School of Biological Sciences
ePrint ID: 56710
Date Deposited: 11 Aug 2008
Last Modified: 27 Mar 2014 18:39
URI: http://eprints.soton.ac.uk/id/eprint/56710

Actions (login required)

View Item View Item