Synaptic modulation of the pharyngeal muscle of C. elegans
Holden-Dye, Lindy and Walker, Robert J. (2002) Synaptic modulation of the pharyngeal muscle of C. elegans. Journal of Physiology, 543P, (S324), p.4S.
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The nematode C. elegans feeds by rhythmic contraction of the pharyngeal muscle. The activity of the muscle is modified by environmental cues, e.g. the presence of E. coli increases the rate of pharyngeal activity. The neural circuit that mediates these effects has been completely mapped. However, the role of neurotransmitters in this pathway is not so clear. To address this we have made intracellular recordings from the pharyngeal muscle and characterised its resting properties (Franks et al. 2002). We have determined the response of the pharynx to putative neurotransmitters and neuromodulators (Rogers et al. 2001). By judicious use of mutant strains (Pemberton et al. 2001), or gene interference, physiologically important signalling pathways may be delineated.
|Subjects:||Q Science > QP Physiology
Q Science > QH Natural history > QH301 Biology
|Divisions:||University Structure - Pre August 2011 > School of Biological Sciences
|Date Deposited:||11 Aug 2008|
|Last Modified:||01 Jun 2011 09:35|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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