Synaptic modulation of the pharyngeal muscle of C. elegans
Synaptic modulation of the pharyngeal muscle of C. elegans
The nematode C. elegans feeds by rhythmic contraction of the pharyngeal muscle. The activity of the muscle is modified by environmental cues, e.g. the presence of E. coli increases the rate of pharyngeal activity. The neural circuit that mediates these effects has been completely mapped. However, the role of neurotransmitters in this pathway is not so clear. To address this we have made intracellular recordings from the pharyngeal muscle and characterised its resting properties (Franks et al. 2002). We have determined the response of the pharynx to putative neurotransmitters and neuromodulators (Rogers et al. 2001). By judicious use of mutant strains (Pemberton et al. 2001), or gene interference, physiologically important signalling pathways may be delineated.
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Holden-Dye, Lindy
8032bf60-5db6-40cb-b71c-ddda9d212c8e
Walker, Robert J.
9368ac2d-f1e9-4bd9-a4b4-4a161c4aa140
1 October 2002
Holden-Dye, Lindy
8032bf60-5db6-40cb-b71c-ddda9d212c8e
Walker, Robert J.
9368ac2d-f1e9-4bd9-a4b4-4a161c4aa140
Holden-Dye, Lindy and Walker, Robert J.
(2002)
Synaptic modulation of the pharyngeal muscle of C. elegans.
Journal of Physiology, 543P (S324), .
Abstract
The nematode C. elegans feeds by rhythmic contraction of the pharyngeal muscle. The activity of the muscle is modified by environmental cues, e.g. the presence of E. coli increases the rate of pharyngeal activity. The neural circuit that mediates these effects has been completely mapped. However, the role of neurotransmitters in this pathway is not so clear. To address this we have made intracellular recordings from the pharyngeal muscle and characterised its resting properties (Franks et al. 2002). We have determined the response of the pharynx to putative neurotransmitters and neuromodulators (Rogers et al. 2001). By judicious use of mutant strains (Pemberton et al. 2001), or gene interference, physiologically important signalling pathways may be delineated.
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Published date: 1 October 2002
Organisations:
Biological Sciences
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Local EPrints ID: 56731
URI: http://eprints.soton.ac.uk/id/eprint/56731
ISSN: 0022-3751
PURE UUID: 5081121a-dc56-4df8-a44a-fcfb6d5c1aa8
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Date deposited: 11 Aug 2008
Last modified: 12 Dec 2021 04:24
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