Role of ERK1/ERK2 and p70(S6K) pathway in insulin signalling of protein synthesis

Sale, Elizabeth M., Atkinson, Peter P.G., Arnott, Caroline H., Chad, John E. and Sale, Graham J. (1999) Role of ERK1/ERK2 and p70(S6K) pathway in insulin signalling of protein synthesis. Federation of European Biochemical Societies (FEBS) Letters, 446, (1), 122-126. (doi:10.1016/S0014-5793(99)00193-3).


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The signalling pathways by which insulin triggers protein synthesis were studied using an antisense strategy to deplete ERK1/ERK2 and rapamycin to inhibit the p70(S6K) pathway. The results indicated that ERK1/ERK2 principally regulated the amount of the protein synthesis machinery available in the cell while the p70S6K pathway contributed to modulating its activation in response to insulin. ERK1/ERK2 also mediated in a small proportion of insulin-stimulated protein synthesis which included the induction of c-fos protein. When c-fos induction was blocked the majority of insulin-stimulated protein synthesis still occurred and thus did not require transcriptional regulation of c-fos or its targets.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1016/S0014-5793(99)00193-3
ISSNs: 0014-5793 (print)
Related URLs:
Keywords: insulin, protein synthesis, extracellular signal regulated kinase 1, extracellular signal regulated kinase 2, p70(S6k), antisense
Subjects: R Medicine > RB Pathology
Q Science > QR Microbiology > QR355 Virology
Q Science > QR Microbiology > QR180 Immunology
Q Science > QR Microbiology
Divisions : University Structure - Pre August 2011 > School of Biological Sciences
ePrint ID: 56751
Accepted Date and Publication Date:
5 March 1999Published
Date Deposited: 22 Aug 2008
Last Modified: 31 Mar 2016 12:37

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