Role of ERK1/ERK2 and p70(S6K) pathway in insulin signalling of protein synthesis
Sale, Elizabeth M., Atkinson, Peter P.G., Arnott, Caroline H., Chad, John E. and Sale, Graham J. (1999) Role of ERK1/ERK2 and p70(S6K) pathway in insulin signalling of protein synthesis. Federation of European Biochemical Societies (FEBS) Letters, 446, (1), 122-126. (doi:10.1016/S0014-5793(99)00193-3).
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Description/Abstract
The signalling pathways by which insulin triggers protein synthesis were studied using an antisense strategy to deplete ERK1/ERK2 and rapamycin to inhibit the p70(S6K) pathway. The results indicated that ERK1/ERK2 principally regulated the amount of the protein synthesis machinery available in the cell while the p70S6K pathway contributed to modulating its activation in response to insulin. ERK1/ERK2 also mediated in a small proportion of insulin-stimulated protein synthesis which included the induction of c-fos protein. When c-fos induction was blocked the majority of insulin-stimulated protein synthesis still occurred and thus did not require transcriptional regulation of c-fos or its targets.
| Item Type: | Article |
|---|---|
| ISSNs: | 0014-5793 (print) |
| Related URLs: | |
| Keywords: | insulin, protein synthesis, extracellular signal regulated kinase 1, extracellular signal regulated kinase 2, p70(S6k), antisense |
| Subjects: | R Medicine > RB Pathology Q Science > QR Microbiology > QR355 Virology Q Science > QR Microbiology > QR180 Immunology Q Science > QR Microbiology |
| Divisions: | University Structure - Pre August 2011 > School of Biological Sciences |
| Item ID: | 56751 |
| Date Deposited: | 22 Aug 2008 |
| Last Modified: | 12 May 2013 01:18 |
| Contributors: | Sale, Elizabeth M. (Author) Atkinson, Peter P.G. (Author) Arnott, Caroline H. (Author) Chad, John E. (Author) Sale, Graham J. (Author) |
| Date: | 5 March 1999 |
| Status: | Published |
| URI: | http://eprints.soton.ac.uk/id/eprint/56751 |
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