Regulation of the phosphorylation of elongation factor 2 by MEK-dependent signalling in adult rat cardiomyocytes
Wang, Lijun and Proud, Christopher G. (2002) Regulation of the phosphorylation of elongation factor 2 by MEK-dependent signalling in adult rat cardiomyocytes. FEBS Letters, 531, (2), 285-289. (doi:10.1016/S0014-5793(02)03536-6).
Download
Full text not available from this repository.
Description/Abstract
The Gq-coupled agonists phenylephrine and endothelin-1 each activate protein synthesis in cardiomyocytes as part of the programme that leads to cardiac hypertrophy. Here we show that they each induce the dephosphorylation of elongation factor (eEF) 2, a protein that in its dephosphorylated state mediates the translocation step of elongation. The ability of both agonists to induce dephosphorylation of eEF2 requires signalling via the mTOR and MEK/Erk signalling pathways, but is independent of phosphoinositide 3-kinase. Expression of an activated form of MEK leads to dephosphorylation of eEF2, in an mTOR independent manner, indicating that signalling via MEK/Erk suffices to cause dephosphorylation of eEF2.
| Item Type: | Article |
|---|---|
| ISSNs: | 0014-5793 (print) |
| Related URLs: | |
| Keywords: | translation, elongation, eEF2, MEK, cardiomyocyte, hypertrophy |
| Subjects: | Q Science > QD Chemistry Q Science > QH Natural history > QH301 Biology |
| Divisions: | University Structure - Pre August 2011 > School of Biological Sciences |
| Item ID: | 56811 |
| Date Deposited: | 07 Aug 2008 |
| Last Modified: | 12 May 2013 01:19 |
| Contributors: | Wang, Lijun (Author) Proud, Christopher G. (Author) |
| Date: | 6 November 2002 |
| Status: | Published |
| URI: | http://eprints.soton.ac.uk/id/eprint/56811 |
Actions (login required)
 |
View Item |
